Terlipressin

Chemical name

N-Триглицил-8-лизин-ваз опрессинацетат

Gross

C52-H74-N16-O15-S2

Of drugs

The drugs-sossoudossouerveshchee, gemostaticescoe. As vazopressin increases tone smooth muscle vascular wall is narrowing arteriol, veins and venul (especially in the abdomen). Decreases in the bloodstream gladkomyshechnykh organs and the liver, reduces pressure gantries system. Has reduce smooth muscle oesophagus, increases tone and makes irritative intestines, stimulates activity Oxytocics whether Beremennosti.posle in / in the amount of the distribution is 0.5 litres. In the liver, kidney and other tissues is active metabolites found in plasma is 30 minutes after injection. Their concentration is maximum in 1-2 hours Vnepochechny Cl-9 ml / kg / min.

Indications

Bleeding from the gastrointestinal (incl. from varikozno expanded veins oesophagus, stomach ulcers and duodenal ulcers), urogenital system, childbirth and abortion, metrorragii different genesis, intraoperaie abdominal and gynaecological (Local) bleeding.

Contraindications

Epilepsy, ischemic heart disease, arterial hypertension, arrhythmia, bronchial asthma, the early stages of pregnancy, toxaemia of pregnancy.

Side-Effects

Headache, paleness, difficulty in breathing, the AD choose ischemia, heart failure, myocardial infarction (rare), increased peristalsis of the bowel (pain in the abdomen, slavery, nausea, vomiting), a d817 reduction in the uterus (pain), necrosis in the ground / m introduction (rarely).

Patient interaction

Increases sosudossouerveshchuu and uterotonicescuu activity oxytocin and metilargometrina, gipertenzivny beta-adrainomimetikov effect. Preparations urejate choose reinforce bradycardia.

Overdosing

Symptoms : cardiovascular disorders (with doses of more than 2 mg every 4 h). Treatment : when expressed increasing AD introduction clonidine (klofelin), and choose less than 50 u. / min-atropine.

Precautions

To apply caution in patients older. Using higher doses of 800 µ g there is a need to control the AD curves and diurez.

Dosing and Administration

In / in, in / m (in exceptional cases), and parameters intrazerwickalno. Bleeding : from the stomach-1000 µ g every 4-6 hours, the expanded veins oesophagus, 3-5 days before stopping and within 2-3 days of the urogenital system, in / in struino for 1 min or infuzionno 200 µ g every 4-6 hours During gynecological operations, timing or intrazerwickalno (400 µ g dissolved in 10 ml of physiological solution), if necessary, increase the dose or enter again.

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