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Macrolides and azalida
The groupThis group comprises natural antibiotics (erythromycin, oleandomitin, spiramizin, etc.) and a number of derivatives of macrolides (roksitromicin, klaritromicin, azithromycin, etc.).
The chemical structure of macrolides is lactonnoe ring, including different antibiotics 14-16 carbon atoms. By lactonnam rings attached various deputies that significantly affect the properties of the compounds.
Mechanism of action of macrolides linked to the embargo limit subjedinistsi ribosomalna membranes and repression Rnk-zawisimogo fusion protein in the microbial cell.
The main feature of derivatives macrolides are improved pharmacokinetic properties with a high (broad spectrum) antimicrobial activity. They are well imbibed and pose in the blood and tissues of long-term continuing high concentration, thus reducing the number of introductions a day to 1-2 times to reduce the length of the course, the frequency and severity of adverse impacts. They DPPB infections in the respiratory tract, infections of the reproductive organs and urinary tract, skin, soft tissue and other infections, by grampolaugitionami and gramotricationami microorganisms many anaerobami, atypical bacteria.