Directory → Antimicrobials, and protivoparazitarnae protivoglistnae funds → Antibiotics → Macrolides and azalida → Azithromycin
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Chemical name9-Деоксо-9а-аза-9а-метил -9а-гомоэритромицин A (and in the form of digidrata)
CharacteristicsThe white crystalline powder.
Of drugsDrugs, the Sun. Associated with the 50S subjedinica ribosom, oppressing peptidtranslokazu being broadcast and suppresses protein biosynthesis, slowing growth and reproduction of bacteria at high concentrations can bakteritidnyi Effect.ustoichiv in acid environment lipofilen rapidly absorbed from the digestive tract. After receiving a single 500 mg material-37% (effect "of a"), C_max (0.4 mg / l) is 2-3 h, the apparent distribution-31.1 l / kg, linking a protein is inversely proportional to the concentration in the blood and is 7-50%, T_1/2-68 p.m. Stable level of plasma achieved in 5-7 days. Easily passes gistogematicalkie barriers and enters the tissue. Also transported faguoqitami, polimorfnoyadernami leikotitami macrofagami and to the site of infection, which produce in the presence of bacteria. Penetrates through the cell membrane (effective for infections caused by vnutricletocnami disease). The concentrations in the tissues and cells of 10 to 50 times higher than in plasma, and the source of infection in the 24 to 34% higher than in healthy tissues. High levels (antibacterial) remains in the tissues within five to seven days after the last injection. Away significantly alter farmakokinetiku (depending on the drug form) : casing C_max reduced (by 52%) and AUC (43%); Suspension - C_max increased (by 46%) and AUC (14%); Pill-growing C_max (31%), no change in AUC. The liver demetiliruetsa, losing activity. Plasma Cl-630 ml / min. 50% return from jelchew unchanged to 6% from urine. The older men (65-85 years old) pharmacokinetic parameters can be changed, women are widening C_max (30-50%) of children aged 1-5 years down C_max, T_1/2, Auc.spectr of broad and includes gram (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, streptococci groups C, F, G, Streptococcus viridans) In resistant eritromitino and gram (Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Campylobacter jejuni, Legionella pneumophila, Neisseria gonorrhoeae, Gardnerella vaginalis) microorganisms anaeroba (Bacteroides bivius, Peptostreptococcus spp. , Peptococcus, Clostridium perfringens), chlamydia (Chlamydia trachomatis, Chlamydia pneumoniae), micobacterium (Mycobacteria avium complex), mycoplasmas (Mycoplasma pneumoniae), ureoplazma (Ureaplasma urealyticum) spiroheta (Treponema pallidum, Borrelia burgdorferi).
IndicationsSexually upper (streptokokkovi pharyngitis and tonzillit) and lower (bacterial exacerbation of chronic obstructive pneumonia, and intersticialnaya alveolarnaya pneumonia, bacterial bronchitis), the respiratory tract, Lor-organov (average otitis, and laringit sinusit), the genitourinary system (Hospital and zerwitzit), the skin and soft tissues (birthmarks, impetigo, secondary infected Medicine), the chronic phase migrant eritema (Lyme disease).
Restrictions on the use ofPregnancy, breast-feeding.
Pregnancy and lactationPerhaps if the effect of therapy outweighs the potential risk to the fetus and the child.
ContraindicationsГиперчувствительност ь (incl. to makrolidam etc.).
Side-EffectsNausea, vomiting, diarrhea, constipation, bloating, pain in the abdomen, melena, holetsatical jaundice, pain in the chest, palpitations, weakness, headache, dizziness, drowsiness, jade, vaginitis, or neutropenia neitrofilia, psevdomembranosny Colitis, candidiasis, photosensitization, skin rashes, swelling angioneuroticeski, eozinofilia; Children also giperkinesia, arousal, nervousness, insomnia, conjunctivitis.
Patient interactionAntatsida containing aluminum hydroxide and magnesium, lower intake (and C_max).
PrecautionsTo use caution expressed in the human liver, kidneys, heart aritmiah (jeludockove possible witness and elongation QT interval). After the treatment response гиперчувствительност и some patients may persist, which requires special treatment under the supervision of a physician.
Dosing and AdministrationInside (1 hour before or two hours after eating), take one every day. Adults with viral upper and lower respiratory tract infections of skin and soft tissues, the first day of 0.5 g, with the 2nd to 5th day - 0.25 g / sut. Dose rate of 1.5 G.pri obstetric diseases, 1 g once; With Lyme disease, 1 g on the first day, with the 2nd to 5th day of 500 mg (dose rate to 3 g). Children over 12 months on the first day, 10 mg / kg, then 4 days to 5 mg / kg or 10 mg / kg / day for 3 days (exchange-dose 30 mg / kg); with Lyme disease on the first day, 20 mg / kg, with the 2nd to 5th day, 10 mg / kg / sut.
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