Erythromycin

Chemical name

[3R-(3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,1 3S*,14R*)]-4[(2,6-Дидезокси-3-��-метил-3-О-метил-альфа- L-рибогексопиранозил)��кси]-14-этил-7,12,13-триги��рокси-3,5,7,9,11,13-гексаме тил-6-[[3,4,6-тридезокси-3- (диметиламино)-бета-D-к силогексопиранозил)о��си]оксациклоте

Gross

C37-H67-N-O13

Characteristics

Crystalline powder white and odourless, bitter taste. It is soluble in water, well, in spirit. Gigroskopichen.

Of drugs

Drugs, the Sun. Reversible contact with the limit subjedinica ribosom in its donor, which blocks the synthesis of proteins sensitive microbial cells, as disrupts the translocation and education peptide linkages between molecules Aminokislot.horosho drawn from the blood, jeluderne content and acid slow absorption. C_max is 0,8-4 g / ml achieved in 2-3 hours after enteralnogo later, and 20 minutes after the on / in the introduction. Connectivity plasma protein variabelna. It enters the body cavity (in the chest, and peritonealna virus fluids concentration of 15-30% of it in the blood), and in the muscle, prostate gland and semen found at concentrations equal to the plasma. Diffuses in poorly krovosnabjaemye organs and tissues (concentration in the average squad of 50% of the found in the blood). Through uncorrupted GEB barely penetrates; Passes through the placental barrier and secretiruetsa in breast milk. T_1/2 is 1-1.2 hours Treated biotransformation in the liver with the formation of active metabolites. Excreted mainly jelchew, with 20-30% of the active form, and 2-8% of the urine. The on / in the introduction with urine output to 12-15%. Breakfast growth and development (of bakteriostaz) a grampolaugitionah - Staphylococcus aureus, Streptococcus pyogenes (beta-gemoliticeski streptokocc Group A), alfa-gemoliticeski streptokocc (Viridans group), Streptococcus pneumoniae, Corynebacterium diphtheriae, Corynebacterium minutissimum, gramotricationah bacteria, Neisseria gonorrhoeae, Legionella pneumophila, Bordetella pertussis and some other micro-organisms, Mycoplasma pneumoniae, Ureaplasma urealyticum, Chlamydia trachomatis, Entamoeba histolytica, Treponema pallidum, Listeria monocytogenes.

Indications

Sexually upper and the lower respiratory tract, SARS гнойно-воспалительны�� diseases of the skin and its appendages, diphtheria, eritrazma, gonorrhoea, syphilis, Listeria, a disease spread, prevention and treatment of diseases in rejecting beta-laktamnah antibiotics; for the eye ointments, conjunctivitis, blefarit, trachoma.

Contraindications

Hypersensitivity, liver disease, pregnancy, breast-feeding (for the period of treatment needed to stop breast-feeding).

Side-Effects

Diarrhoeal disorders (nausea, vomiting, pains in the abdomen, etc.), disruption of the liver, Generalized convulsions, hallucinations, human consciousness, dizziness, forming hearing impairment, ventricular tachycardia, elongation QT interval.

Specific guidance

Using erythromycin containing benzene, for a / in the injection sometimes accompanied by the development of the fatal syndrome Gaspinga children, as well as acute hepatitis drug in adults and children.

Patient interaction

Potenziruet effects and toxicity antigistaminnah preparations alkaloids LPV, theofillina and benzodiazepines, digoxin, anti indirect type actions carbamazepina, cyclosporine, gexobarbitala, fenitoina, alfentanila, dizopiramida, lovastatina and bromokriptina.

Overdosing

Symptoms : disruption of the liver until acute liver failure, and loss Sluha.lechenie : washing stomach, big diurez, diagnostic and peritonealny dialysis. A constant monitoring vital functions (ECG, elektrolitny blood).

Dosing and Administration

Inside for 1.5-2 hours before delivery; Adults : 250 mg four times a day; Highest single dose 500 mg daily 2 g; Children : from 1 to 3 years, 400 mg / day, from 3 to 6 years, 500-750 mg / day, from 6 to 8 years - 750 mg / day, from 8 to 12 years up to 1 g / day, divided into 4 Priema.v / to give adults and children at the rate of 15 to 20 mg / kg / day in the form of permanent or intermittent infusions. In severe cases, there may be higher dosage to 4 g / sut. External, 2 times a day cuticles solution infection looks skin ointment were in the area of destruction, in case an eye for the bottom or top cat 3-5 times a day.

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