Oleandomycin

Chemical name

[3R-(3R*,5R*,6S*,7R*,8R*,11R*,12R*,13R*, 14S*,15S**)]-12-[(2,6-Дидезокси - 3 -0-метил-альфа-L-арабин��гексопиранозил)окси]- 6-гидрокси-5,7,8,11,13,15- �ексаметил-14-[[3,4,6-трид��зокси-3-(диметиламино) -бета-D-ксило- гексопиранозил]окси]-1 ,9-диоксаспиро[2.13]гек

Gross

C35-H61-N-O12

Characteristics

Antibiotics from the macrolides, producyruemy radiant fungus Streptomyces antibioticus or other related diseases. Crystalline powder or porous mass of white or white with a yellowish sheen color, bitter taste. Easily soluble in water, soluble in diluted solutions of acids, it is readily soluble in ethanol, gigroskopichen.

Of drugs

The drugs of anti - (бактериостатическое) . Ingibiruet microbial synthesis of proteins at the level of ribosom (breaks education peptide linkages and increase circuits 40b). Provides bacteriostatic action against grampolaugitionah (Staphylococcus spp. , And producyrute neproducyrute penitsillinazou; Streptococcus spp. , Including S. pneumoniae; Bacillus anthracis, Corynebacterium diphtheriae) and some gramotricationah microorganisms (Neisseria gonorrhoeae, Haemophillus influenzae, Bordetella pertussis, Brucella spp. , Legionella spp.) , And Mycoplasma spp. , Chlamydia spp. , Treponema spp. , Rickettsia spp. Weak against coliforms and other gramotricationah coliform Group.malotoksicen has no cumulative Swoystwami.horosho absorbed by ingestion, quickly spread into many organs and body fluids. It permeates through uncorrupted GEB. S_max achieved after 1-3 hours, therapeutic concentration maintained in the blood over a period of four to five hours (with the re-introductions to 8 hours). Report the news and jelchew.

Indications

Pneumonia, pleurisy, lung abscess, empiema pleura, bronhoektasia, tonzillit, otitis, scarlet fever, diphtheria, whooping cough, trachoma, protracted endocardit, meningitis, sepsis (stafilokokkovi, streptokokkovi, pnevmokokkovi) osteomielit, furunkoulez, gonorrhoea, enterocolitis, urinary infections and Biliary Diseases (if not struck by the liver parenchyma), and other diseases caused by microorganisms sensitive oleandomitino, incl. in the resistance to other antibiotics (especially penitsillinam).

Pregnancy and lactation

During pregnancy and lactation appointed with caution.

Contraindications

Hypersensitivity, the defeat parenhima liver.

Side-Effects

Allergic reaction (skin itching, urticaria, angioneuroticeski swelling), nausea, vomiting, diarrhea.

Specific guidance

In order to prevent the development of resistance to microbial combination with other antimicrobial means, especially тетрациклином.Следуе�� Note that 1 mg product contains not less than 750 U. U 1 on the activity 2.4.3 oleandomitina grounds.

Patient interaction

Is combination with tetratziklinami, hloramfenikolom, levorinom, nistatinom, sulfanilamidami.

Dosing and Administration

Inside, after delivery of 0.25 grams of 4-6 times a day. Higher doses for adults :, 0.5 grams daily-2 and higher daily intakes for children : up to 3 years, 0.02 g / kg, from 3 to 6 years - 0.25 g of 6 to 14 years 0.5-1 g over 14 years, half the city course of treatment is 5-7 days.

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