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Roksitromicin leks

See also Roxithromycin

Roman name

Roxithromycin Lek

The composition and the form of

1 tablet, film coated liner contains roksitromitina 150 or 300 mg; in a contour acheikova packing 10 (150 mg) or 7 (300 mg) pcs. , in a cardboard bundle one package.

Of drugs

Sun broad spectrum. Violate vnutricletocny fusion proteins microorganisms. Good penetration of the cell performance against intracellular pathogens (Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma pneumoniae). The drug sensitive : Staphylococcus spp. (excluding метициллинорезистент ные strains), Streptococcus spp. , Corynebacterium, Bacillus cereus, Listeria monocytogenes, Neisserria gonorrhoeae, Neisserria meningitidis, Bordetella pertussis, Helicobacter pylori, Gardnerella vaginalis, Branhamella (Moraxella) catarrhalis, Legionella Pneumophila.effectiven on anaerobic microorganisms : Bacteroides oralis, B.melaninogenicus, B.urealiticus; Clostridium perfringens; Eubacterium, Peptococcus, Peptostreptococcus, Propionibacterium acnes. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma pneumoniae, Rickettsia R.conorii.nepermanno sensitive : Haemophilus Influenzae.k drug resistant : Bacteroides fragilis, Clostridium difficile (most resistant strains); Pseudomonas, Acinetobacter, Enterobacteriaceae.

Pharmacokinetics

Rapidly absorbed from the intestine after oral intake. Compared with other makrolidami more stable in the acidic environment (admission 15 minutes before the food has no effect on skin). C_max plasma (range 6-8 mg / l) is the 2 h after administration of doses of 150 mg. Admission drug every 12h maintains effective concentrations in the day. In small amounts (0.05% dose) secretiruetsa in breast milk. Many high penetration into tissue (lungs, nebnye pyelonephritis, presentatelnuu iron), the liquid and the cells (macrofagi). Partly metabolised in the liver, 50% displayed intestinal unchanged to about 12% kidney, and about 15% Light. T_1/2 after a single dose received 150 grams is about 12 hours In the absence of the liver increases the half, and the maximum concentration in plasma.

Indications

Infections caused by Mycoplasma, Chlamydia, Legionella; Infection caused by microorganisms sensitive penitsillinam and zefalosporynam, incl. in patients with high sensitivity. Sexually upper (tonzillit, pharyngitis, laringit, sinusit, diphtheria, pertussis), and lower respiratory tract infections (pneumonia, bronchitis), skin and soft tissue (including ordinary acne, gas gangrene); Average otitis, odontogenne infections; Acute gastroenterokolit caused by Campylobacter jejuni; Saying disease duodenal ulcers and chronic gastritis caused by H. pylori; chronic prostatitis, prevention of rheumatic fever.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy. In II and III trimester of pregnancy only for health reasons, under the close supervision of a physician. While breast-feeding is possible only under the close supervision of a physician.

Contraindications

Hypersensitivity, I trimester of pregnancy; Porphyria.

Side-Effects

Side effects are rare and do not require the Preparata.so part of the intestine : possibly nausea, vomiting, flatulence, Diarea.allergicakie reactions : skin rashes, erythema. The patients sensitive to the immediate reactions гиперчувствительност и (angioneuroticeski swelling, bronhospazm, anaphylactic shock). Perhaps the �уперинфекции.Имеются �tdelne Reports of increased body temperature and increase in the Eozinofilov.redko - tranzithornoe increases in the levels of liver transaminaz and alkaline phosphatase, it is rarely obratimaya liver failure.

Patient interaction

Together with the application of preparations containing ergotamine, digidroergotamin and other diseases Secale cornutum, sossoudossoujiwatmi ergotaminopodobnami means possible arterialnogo development stages and Ischemia. Increases the absorption of digoxin concentration racumin (protrombinovoe longer time). The combined application with theofillinom ziklosporinom or more whey of the latest (correction mode is not required). If you are a group of antibiotics macrolides with terfenadine, cizapridom, astemizolom may develop severe complications of the circulatory system, including fibrillation, began testing and other jeludockove adults. Together with the application roksitromitinom such complications were observed (caution). If you are applying etambutola a synergy with Mycobacterium avium.

Overdosing

Symptoms : Symptoms increased by Reackzi.lechenie : washing stomach and symptomatic treatment. Specific antidote exists. Haemodialysis ineffective.

Precautions

Be wary appointed to liver failure (only for health reasons, with the periodic monitoring of liver function and the correction mode).

Dosing and Administration

Inside, the food, squeezed enough liquid. Vesroclam and children over 12 years of age (with a mass of 40 kg) : 300 mg / day, 150 mg every 12 hours or 300 mg every 24 hours Children under 12 years of age, with body mass index of at least 30 kg : 5-10 mg / kg / day in 2 admission. While liver and severe renal failure (Cl creatinine less than 15 ml / min) : 150 mg every 24 hours The course of treatment is 14 days.

Storage conditions

tabl.p.p.o. : List B.

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