Directory Antimicrobials, and protivoparazitarnae protivoglistnae funds Antibiotics Macrolides and azalida Vrsac
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Vrsac

See also Azithromycin

Roman name

Hemomycin #

The composition and the form of

1 capsule contains azithromycin 250 mg; in blistere 6 pcs. , in the box one blister.

Of drugs

Sun (bactericidal). In high concentrations has a bactericidal effect. Active against grampolaugitionah kokkov (Streptococcus pneumomiae, Streptococcus pyogenes, Streptococcus agalactiae, sterptokocchi CF group and G, Staphylococcus aureus, Staphylococcus viridans), gramotricationah bacteria (Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophilia, Haemophilia ducrei, Campylobacter jejuni, Neisseria gonorrhoeae, Gardnerella vaginalis), certain anaerobic microorganisms (Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp) and Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi. Not against grampolaugitionah bacteria resistant to eritromitino.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal (due to its resistance in acidic media and lipophilicity). Once inside the dose of 500 mg C_max achieved through 2,5-2,96 h is 0.4 mg / O Bioavailability was 37%. Distribution. It enters the respiratory tract, organs and tissues genital tract, in the skin and soft tissue. High concentrations in the tissues (10 to 50 times higher than in the blood plasma), and a long period of half due to low binding AIDS with blood plasma proteins, as well as its ability to infiltrate the eukarioticalkie cells, and concentrate on lizosomah. This is a large volume of distribution (31.1 l / kg) and high plasma klirens. The ability of HIV to accumulate mainly in lizosomah particularly important to eliminate intracellular pathogens. Faguoqita azithromycin taken in the localization of infection, which he released in the process of phagocytosis. The concentration of HIV in infected areas is higher than in healthy tissues (by an average of 24-34%), and correlated with the degree of inflammatory pain. Despite the high concentration in faguoqitah, azithromycin has had little discernible impact on their Funktia.azitromicin persists in killing concentrations in the middle of inflammation within 5-7 days after taking the last dose, which had enabled the development of short courses Lechenia.vwoditsa in two phases : T_1/2 first phase (in the range of 8-24 h), p 14-24, second (in the range of 24-72 hours), 41 hours

Indications

Sexually upper divisions respiratory and throat bodies (angina, sinusit, tonzillit average otitis), fever, infections divisions lower respiratory tract infections (bacterial and SARS, bronchitis), infections of the skin and soft tissues (birthmarks, impetigo, a second infected dermatos), the genitourinary system (neoslojnenny promoted and / or zerwitzit), Lyme disease (for the treatment of early stage) diseases of stomach and duodenal ulcers associated with Helicobacter pylori.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus and infant.

Contraindications

Гиперчувствительност ь (incl. other makrolidam).

Side-Effects

For part of the intestine : nausea, diarrhoea, pain in the abdomen; Rarely flatulence, tranzithornoe increase in liver Fermentov.so the skin : in some cases, rashes.

Patient interaction

Antatsida reduce intake (recommended suspension of not less than two hours after or before receiving antatsidov).

Precautions

Be wary appoint patients with acute human liver and kidneys.

Dosing and Administration

Inside, every day, for one hour before meals or two hours after Eda.infection upper and lower divisions of the respiratory tract, skin and soft tissue : 500 mg / day for 3 days; Exchange dose-1500 Mg.neoslojnenny promoted and / or zerwitzit : one in 1000 Mg.bolezn disease : 1000 mg on the first day and 500 mg in 2-5-i days (exchange dose 3,000 mg). Diseases of stomach and duodenal ulcers associated with Helicobacter pylori : 1000 mg / day for 3 days in a combination Terapii.pri pass reception missing dose should be taken as soon as possible, and the other with an 24-hour

Storage conditions

caps. : List B. In dry the dark place at a temperature of 15-25 ° C

Shelf life

caps. : 2 grams.

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