Tetracycline

Chemical name

[4S- (4alfa .4 and .5 alpha alpha and beta .6 .12 and альфа)]-4-(Диметиламино )-1,4,4а,5,5а,6,11,12а-октагид ро-3,6,10,12,12а-пентагидро кси-6-метил-1,11-диоксо-2- нафтаценкарбоксамид (and as hydrochloride or trigidrata)

Gross

C22-H24-N2-O8

Characteristics

Yellow crystalline powder odourless, bitter taste. Very little is soluble in water, it is difficult in alcohol, is highly soluble in solutions of strong acids and alkalis. Gigroskopichen. The dark world.

Of drugs

The drugs-antimicrpobial, Sun (бактериостатическое) . Violate the formation of the complex between transport and RNA ribosoma, resulting in the violation of protein synthesis. It has a wide range of activity. Active for most grampolaugitionah and gramotricationah microorganisms affects spiroheta, leptospira, rickettsia, Virusa.posle large intake of rats to 66% of the doses. Associated with the supply by 65%. It penetrates into the various organs and tissues, as well as biological fluids : elixirs, sinovialnuu, astiticescuu, cerebrospinal (in the last concentration of 10-25% of such plasma), selectively accumulates in the bones, liver, spleen, tumours, teeth. Passes through the placenta and breast milk. Metabolizmu not be. Excreted kidneys and jelchew.

Indications

Aktinomikoz, bronchitis, pneumonia, fever, conjunctivitis, urinary infection ways gingivit, disease, the average otitis, pharyngitis, sinusit, psittakoz fever rocky mountains Ku fever, syphilis, trachoma, dysentery, tonsillitis, whooping cough, scarlet fever, gonorrhea, tularaemia, typhoid, bacterial endocardit, eight meningitis, holetsistit, infections of the skin and soft tissues.

Contraindications

Hypersensitivity, disruption of the liver and kidney failure, pregnancy, breast-feeding (at the time of treatment cease breastfeeding), children's age (up to 8 years).

Side-Effects

Diarrhoeal phenomenon to liver and kidney failure, pancreatitis, dizziness, refers, the precariousness of walking, pigmentation of skin, mucous membranes, tooth enamel in children, the vnutricerepnogo pressure goiter, gipovitaminoz, photosensitization, allergic reactions.

Patient interaction

Antatsida, salt, calcium, magnesium, iron, holestiramin-less induction of the digestive tract. Decreases effectiveness of oral contraceptives and the risk of uterine bleeding, decreased activity bactericide. Increases nefrotoksicnosti metoksiflurana. When coupled with vitamin A increased the risk of intracranial hypertension.

Dosing and Administration

Inside, adults on the 250 mg four times a day. For children over the age of eight years in the 6,25-12,5 mg / kg every 6 h or 12,5-25 mg / kg every 12 hours The course of treatment is 5-7 days. External applied several times a day, if necessary, impose a weak band. Intrakongungualno, 3-5 times a day.

Directory → Antimicrobials, and protivoparazitarnae protivoglistnae funds → Antibiotics → Tetratziklin → Tetracycline