Methenamine

Chemical name

1,3,5,7-Тетраазатрицикло [3.3.1.1]декан (and in the form of angidrometilenzitrata, kamforata, gippurata, indigocarminata or mandelata)

Gross

C6-H12-N4

Characteristics

Clear crystals or white crystalline powder jguchego and sweet, then bitter taste, odourless. Easily soluble in water and alcohol. The heating surface is not razlagaacy. On colourless flame. Aqueous solutions are alkaline reaction.

Of drugs

The drugs-antimicrpobial. Active for most microorganisms that cause disease urinary tract. Provides dozozawisimy bakteritidnyi or bakteriostaticeski effect. Is prolekarstvom after splitting in acidic urine release formaldehyde, denaturiruty protein structure germs. Quickly and completely absorbed in the digestive tract. Bioavailability - 30-60%. The blood plasma proteins little contact. Up in the urine clubockova filtering and kanalzeva secreta. C_max in the urine in 2 hours T_1/2-4.3 hours Excreted kidneys, 90% return within 24 hours

Indications

Urinary tract infections.

Restrictions on the use of

Pregnancy; No information on the safety of the children under 6 years of age and lactating women.

Contraindications

Hypersensitivity, dehydration organism, renal and hepatic failure.

Side-Effects

Diarrhoeal phenomenon : nausea, vomiting, diarrhoea, pain in the abdomen; Defeated parenhima kidney albuminemia, gematuria, christalluria, allergic reactions : skin rashes and itching of the skin; Redness and soreness at the injection.

Patient interaction

Preparations zashchelacivate urine (antatsida, carboangidraza inhibitors, sodium bicarbonate, citrata, tiazidnye dioretiki), reduces efficiency.

Dosing and Administration

Inside, in the 0.1-1 g twice Sutki.v / in introducing 5-10 ml of 40% solution of the preparation. The course of treatment is determined individually.

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