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KelfiprimSee also Emetine hydrochlorideRoman nameKelfiprimThe registration003,776 (Ann.1999)Of drugsCombined sulfanilamidnyi preparation consisting of sulfalena and trimetoprima. And microbicides (destroying bacteria) effect. The mechanism of action of the preparation is consistent enzyme blockade two stages metabolism (exchange) folic acid in the bacterial cell and then down the biosynthesis of nucleic acids and loss of bacterial cells. The drug has a wide range of activity, active against grampolaugitionah kokkov, shorten, Bordetella, Klebsiella pneumoniae, Aerobacter, Shigellae, vibriona cholera, as well as Haemophilus influ-enzae, Escherichia coli, Proteus mirabilis, Proteus vulgaris, Serratia marcescvens.Indications for useAcute and chronic respiratory tract infections : tonzillit (inflammation nebnykh mindalin / gland), sinusit (inflammation okolonosovykh sinuses), pharyngitis (inflammation of the pharynx), bronchitis (inflammation of the bronchi), bronhoektaza (bronchus disease characterized by a sharp increase in the clearance), pneumonia (pneumonia); Acute and chronic urinary infection ways : anesthetic (inflammation of the bladder), pielit (inflammation of kidney lohanki) prostatitis (inflammation of prostate cancer), Baby (inflammation mocheispuskatelland channel), day (testicular inflammation), epididimit (inflammation of testicular appendages); infections of the gastrointestinal tract : enteritis (inflammation of small bowel), typhoid fever, inc; piogenne (gnoerodne) infections of the skin and soft tissues : piodermia (purulent inflammation of the skin), furunkula (purulent inflammation guess bag skin spread to the surrounding tissue), abscesses (bleeding); prevention of pre - and postoperative infections.Dosing and AdministrationBefore you assign patient drug to determine sensitivity to the hair that caused the disease in a particular patient. Adults and children over 12 years of age shall product, as follows : 1st day of the treatment-two capsules on one occasion; Beginning with the 2nd day and the one-capsule morning. Children under 12 years of age capsules appointed dose of 4 mg / kg trimetoprima + 3.2 mg / kg sulfalena every 12 hours (maximum dose of 100 mg trimetoprima + 80 mg sulfalena). Syrup children from the ages of 3 to 12 months appoint 2.5 ml every 12 hours; From 1 to 3 years to 5 ml every 12 hours; 3 to 6 years in the 7.5 ml every 12 hours; from 6 to 12 years, to 10 ml every ability. Course drug treatment should be not less than 5 days.Side-EffectsHeadache, gastralgia (pain in podlojecna area), nausea, vomiting less, glossit (inflammation language), erythema (reddening limited skin). In rare cases, after long-term care insurance can be thrombocytopenia (decrease in the number of platelets in the blood), lakopenia (to reduce blood in the blood), neutropenia (decrease in the number of Klebsiella in the blood), agranulozitos (dramatic decrease in the number of granulozitov in the blood), which are independently after preparation.ContraindicationsHypersensitivity to trimetoprimu and / or sulfanilamidam; Expressed human liver and kidneys; Pathological changes in the blood picture; Glukozo-6-fosfatdegid-rogenaza deficit; Pregnancy, breast-feeding. The agent is not appointed for children up to three months.Form ofThe capsules, containing 0.25 g trimetoprima and 0.2 g sulfalena, in a package of 12 pieces; Syrup (for children) in vial of 100 ml (1 ml - 0.01g trimetoprima and 0.008 g sulfalena).Storage conditionsList B. In a dry, the dark spot. |
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