Mebendazole

Chemical name

Methyl ester (5-бензоил-1Н-бензимида зол-2-ил)карбаминовой acid

Gross

C16-H13-N3-O3

Characteristics

Belovato-jeltovaty powder soluble little (less than 0.05%) of the water, aqueous solutions of mineral acids, alcohol and chloroform, well, in the ant acid.

Of drugs

Drugs, the anthelminthic. Prevents cellular synthesis tubulina violates glucose utilization and hampers education ATF from Helmintov.medlenno and partially (10% dose) extracted from the blood. T_1/2-2.5 hours In the blood of 90% is associated with malnutrition. The unequal distribution of organs. Collected in adipose tissue, liver, licinkah worms. The liver biotransformiroetsa 2-aminpirizvodnyi before. More than 90% return rate unchanged to the faeces.

Indications

Enterobios, ascariasis, ankilostomidozy, strongiloidoz, trihozefalez, multiple nematodozy, disease, tenios, alveokokkoz, kapillarios, gnatostomoz, trichinosis, mixed gelmintozy.

Contraindications

Hypersensitivity, Baby Ulcerative Colitis, ulcerative disease, liver dysfunction, tranzithornoe increasing aminotransferaz, alkaline phosphatase, and blood urea, reduced hemoglobin, pregnancy, breast-feeding (at the time of treatment should stop breastfeeding), children up to 2 years.

Side-Effects

Dizziness, headache, disruption of endocrine, neutropenia, hair loss (in high doses), allergic reactions : increased body temperature, skin rashes, itching of the skin.

Patient interaction

Carbamazepine, etc. induktora lower metabolism and zimetidin increases the concentration in the tissues.

Overdosing

Symptoms : nausea, vomiting, diarrhoea, pain in the stomach. With long-term use at high doses : reversible functions of the liver, hepatitis, Neitropenia.lechenie : washing stomach enema reception activated carbon; Specific antidote not.

Precautions

Application during lactation requires switching to artificial feeding. Be sure to periodically study anal swab and stool after the end of treatment : therapy is effective in the absence of worms or their eggs for a period of 7 days. There is a need to avoid the use of joint with alcohol and fatty food slabitionami drugs. The picture control peripheral blood, liver and kidneys.

Dosing and Administration

Inside. In enterobiose-adults and adolescents 100 mg, children 2-10 years, 25-50 mg once and again in 2-4 weeks in the same Dozah.pri askaridoze, trihozefaleze, ankilostomidoze, teniose, strongiloidoze and mixed-gelmintozah 100 mg morning and evening for a three Dnei.pri trihinelleze-400 mg three times daily for 3 days and from the 4th to 10th on the 400 mg three times a Sutki.pri ehinokokkoze on 500 mg twice a day the first three days and three times a day over the next three days. Later appoint 25 to 30 mg / kg / day in 3-4 reception.

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