Amorolfine

Chemical name

({+})-цис-2,6-Диметил-4-[2-м��тил-3-(п-трет-пентилфе��ил)пропил]морфолин (and as hydrochloride)

Gross

C21-H35-N-O

Of drugs

The drugs-antimycotic (fungicidal, fungistaticescoe). Damaged cell membrane mushrooms from the oppression of enzymes involved in biosynthese sterols. Reduction of ergosterina contributes to the accumulation of abnormal neploscostnykh stereoisomers sterols. There is a wide range of actions, good for yeast fungi (Candida, Malassezia, Cryptococcus) dermatomycosis (Trichophyton, Microsporum, Epidermophyton) molds (Alternaria, Hendersonula, Scopulariopsis) dimorfnah fungus (Coccidioides, Histoplasma, Sporothrix), mushrooms Dematiaceae (Cladosporium, Fonseceae, Wangiella) and Aktinomicetov.pri software in the form of CD enters nogtevu plate and diffuses into nogtevoe bed, Cream of rapidly distributed in the deep layers of skin.

Indications

Onihomikozy (treatment and prevention), by dermatofitami, yeast and fungi plesnevami; Dermatomikozy due dermatofitami : mikozy feet groin limbs, hands, as well as kandidozy skin otrubevidnyi zoster.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (at the time of treatment should be suspended), the period of birth and a young child.

Side-Effects

Burning, erythema, skin in fashion.

Precautions

Kremlin not to the great and / or erozirovanne surface. Using varnish preclude work with organic solvents (need to wear tight gloves), the overhead of artificial nails.

Dosing and Administration

External. In onihomikozah varnish applied on the affected nails 1-2 times a week. Before using waste sites affected by the attached disposable gloves, clean surface ready swabs, smochennami alcohol; Before the next applikaciei repeat procedure previously removing varnish residue swab with alcohol. Treatment continues incessantly until vrastania new nail and disappearances affected sites. Length of therapy depends on the location and extent of, and an average of 6 months (his fingers brushes), or 12 months (his fingers feet).

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