Amphotericin b

Chemical name

[1R-(1R*,3S*,5R*,6R*,9R*,11R*,15S*,16R*, 17R*,18S*,19E,21E,23E,25E,27E,29E,31E,33 R*,35S*,36R*,37S*)]-33-[(3-Амино-3, 6-дидезокси-бета-D-манн опиранозил)окси]-1,3,5,6,9 ,11,17,37-октагидрокси-15,16 ,18-триметил-13-оксо-14,39-��иоксабицикло[33.3.1]нон��триаконта-1

Gross

C47-H73-N-O17

Characteristics

Powder yellow or jelto-oranjevogo color. Virtually nerastvorim in water and alcohol. Gigroskopichen, sensitive to sunlight and high temperatures. Easily inaguiruetsa in acidic and alkaline media.

Of drugs

The drugs-antimycotic (fungicidal). And antifungal effect for many pathogenic fungi pathogens various deep and systemic mycosis. Associated with the component sterolovam zitoplazmaticescoy membranes violates its barrier function and cause lysis mushrooms. After the on / in the 1-5 mg / day C_max plasma-0.5-2 g / J Connectivity blood protein-more than 90%. Hardly dializiruetsa easily penetrates the tissues (but not in the water environment and the organism serosnye cavity). Metabolised in bile and urine of about 98% amfoteritina present in the form of metabolites. Return slowly (kidney), T_1/2 is 15 days. Following the lifting detected in the body for a few weeks.

Indications

System-mikozy kandidomikoz, aspergillez, gistoplazmoz, kriptokokkoz, koktsidiomikoz, blastomikoz, lung mikozy (aktinomikoz), anesthetic, leishmaniasis.

Restrictions on the use of

Pregnancy (restricted for health reasons).

Contraindications

Hypersensitivity expressed by the human liver and kidney diseases of blood, and diabetes mellitus.

Side-Effects

Fever, anorexia, loss of body weight, nausea, vomiting, diarrhoea, human liver and kidneys, headache, neurological damage, hypothetical or hypertension, ECG changes, hearing or sight, a decline in hemoglobin, thrombocytopenia, gipokaliemia, anaphylactoidnye reaction throm possible in the injection.

Specific guidance

In the treatment needed to be monitored as the liver, kidneys, blood and the level of potassium in the blood.

Patient interaction

Could the impact of cardiac glycosides and kurarepodobnykh miorelaksantov. Incompatible with nefrotoksicnami antibiotics and protivoopujolevami drugs.

Overdosing

There utageleniem side effects and possible cardiac arrest and Dahania.lechenie : symptomatic.

Dosing and Administration

In / in, inhalation and Local. To determine the acceptability initial dose for the on / in the 100 µ g / kg body weight. The average dose of 250 µ g / kg If necessary, can increase daily doses up to 1 mg / kg Assign a day or two times a week.

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