Diflukan

Roman name

Diflucan #

The composition and the form of

1 capsule contains flukonazola 50, 100 or 150 mg; in blisterh to 7 pc. (50 and 100 mg), or 1 pc. (150 mg), in one box blister.1 ml for on / in infusions to 2 mg; in glass bottles of 50 ml, in a Box 1 flakon.5 finished ml suspension for admission into the 50 - or 200 mg; plastic bottles of 60 ml, complete with enough drugs, in the box one bottle.

Of drugs

Antimycotic. Synthesis inhibitor sterols in the cell mushrooms. Does a zitohrom dependent P450 enzymes and stops sterols synthesis in cells mushrooms.

Indications

Tumours (generalizirovanny, disseminated, orofaringealny vaginal, mucous membranes, skin and nails), kriptokokkoz, candidemia, prevention candidiasis in different groups of patients.

Pregnancy and lactation

Not recommended.

Contraindications

Гиперчувствительност ь.

Side-Effects

Nausea, vomiting, pain in the abdomen, bloating, diarrhea, rash, headache; In very rare cases, when compared with other major diseases, changes in the liver and kidneys, convulsions, lakopenia, thrombocytopenia, alopecia, exfoliativee skin (syndrome Stevens-Johnson, toxic It'sa nekrolizis) and anaphylacticskie reaction.

Patient interaction

Do effects of anticoagulants, drugs sulfonylureas, gidrohlorotiazida, fenitoina increases the concentration of plasma Cyclosporine, theofillina, alone; Off Diflukana rifampitsinom accelerated.

Dosing and Administration

Inside, in / 386/1989 Adults, in kriptokokkovh infections, kandidemy, disseminirovannom 4-8 400 mg on the first day, and then on 200-400 mg / sut. In orofaringealnom 4-8 on 50-100 mg once a day for prevention of AIDS, 150 mg once a week. In waginalnom 4-8-one, inside, in the dose of 150 mg. To prevent candidiasis-front mg once a day. The skin infections - 150 mg once a week or 50 mg once a Sutki.detam, with the 4-8 mucous membranes to 3 mg / kg / day, generalizovanny candidiasis and kriptokokkoz, 6-12 mg / kg / day, prevention, 3-12 mg / kg / day; The first two weeks of life is the same dose (in mg / kg), that of the older children, but at intervals of 72 hours; 2-4 weeks is the same dose at intervals of 48 hours. The homemade suspension for admission into vesboltati feet to razrahliti powder, add 24 ml of water and vesboltati well. Each of the skin suspension for the reception inside to stir.

Storage conditions

caps. : When temperature is not above 30 ° Cpor.d / susp. for the reception inside : When temperature is not above 30 ° Cr-r d / inf. : When temperature is not above 30 ° C

Shelf life

caps. : 5 letpor.d / susp. for the reception inside : 3 City. 14 d after cooking suspenzii.r-r d / inf. : 5 years

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