Econazole

Chemical name

1-[2-[4-Хлорфенил)метокс��]-2-(2,4-дихлорфенил)эти��]-1H-имидазол (and in the form of nitrate)

Gross

C18-H15-Cl3-N2-O

Of drugs

The drugs-antimycotic (fungicidal), Sun (bactericidal). Stops biosynthesis ergosterola regulating the permeability of cell walls of microorganisms. Easily soluble in lipids and well penetrates the tissues. Active against dermatomycosis (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, Epidermophyton floccosum, as well as Candida albicans and Pityrosporum orbiculare), mould fungi (Aspergillus, Cladosporium, Scopulariopsis brevicautus) and some grampolaugitionah bacteria (streptococci, staphylococci). Following application on the skin absorption system negligible long found in rogovom layer in concentrations sufficient to fungizidnyi action. Clinical effect develops over a period of three days of treatment.

Indications

Dermatomikozy smooth skin dermatofitia feet skin candidiasis, a multicolored zoster, onihomikozy. In gynaecological practice vulvowaginale kandidozy (molocnica) kolpita, fungal balanita (the sexual partner), mikozy, cause superinfekciei grampolaugitionami bacteria.

Contraindications

Hypersensitivity, pregnancy.

Side-Effects

Local reactions : pain, a sense of stinging and itching, red skin rashes; In the long-term use - and hyperpigmentation atroficskie skin lesions.

Precautions

To prevent the recurrence and kandidozov dermatomikozov legs and torso required treatment of at least two weeks, and dermatofitia feet is not less than 1 month; In the absence of effect on the dates therapy should be discontinued and the diagnosis. In the case of insufficient standard three day course in the 4-8 waginalnom it may be continued for 3 days and some of the next 10 days. When the first symptoms, indicating a high degree of sensitivity, or irritation, econazol must be eliminated. We recommend caution when appointing lactating women. During menstrual bleeding medication intrawaginalno enter in the usual way. In vulvowaginalnah mikozah to treatment and sexual partner.

Dosing and Administration

Locally. Sufficient creams are thought to the site of skin and gently scrub; A procedure once a day with dermatomikoze feet, legs and torso, raznotsvetnom inhabitants, twice a day (morning and evening), with the skin kandidozah. Aerosol - raspalaut from a distance of 10 cm on the skin and easy to scrub. Shoe : intrawaginalno (with a special applikatora) in the trunk (at night), every day, 3 days at a time. Surgical candles impose deep in the rear set vagina overnight during 3-15 days.

Literature

VN Prilepskaya Genital candidiasis. Modern approach to the treatment / / OBGYN-1996-N-6 S. 28-29.

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