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FungolonSee also FluconazoleRoman nameFungolonThe composition and the form of1 capsule contains flukonazola 50, or 100 mg; blistere in PVC / aluminium foil 8 pcs. , the paper cartons 1 or 2 blisters.Of drugsAntimycotic. Yes ingibiruet sterolov synthesis in cells mushrooms.PharmacokineticsWell drawn from the blood, eating does not affect the removals. C_max achieved through 0.5-1.5 h Linking plasma protein-11-12%. Equilibrium concentration is 4-5 in day care (to 1 per day). It enters the body fluids organism. Report mostly kidneys, 80% in an unmodified form. T_1/2 about 30 hours Ground proportional klirensu creatinine.FarmakodinamikaActive against Candida spp. , Cryptococcus neoformans, Microsporum spp. , Trichophyton spp. , Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum.IndicationsKriptokokkoz : chriptokokkovi meningitis, infections of the skin and light; Prevention of the recurrence of cryptococcosis in AIDS patients; Generalizovanny candidiasis : candidemia, disseminated candidiasis and other forms of invasive infections kandidozhnykh (defeated edge, endocarda, eyes, respiratory and urinary tract); Candidiasis mucous membranes of the oral cavity and pharynx, oesophagus, bronholegocny candidiasis, candiduria, kandidozy skin and mucous membranes, atroficski candidiasis of the oral cavity (associated with carrying dentures), the prevention of relapse orofaringealnogo candidiasis in patients with AIDS; genital candidiasis : vaginal (acute or recurrent), including relapse prevention, kandidozny balanit; prevention of fungal infections in malignant tumors; mikozy skin (feet, body shapes field), otrubevidnyi zoster, onihomikoz, skin candidiasis; deep endemic mikozy (koktsidiomikoz, parakoktsidiomikoz, sporotrihoz, gistoplazmoz) in patients with nenarushennym immunity.Pregnancy and lactationWhen pregnancy is possible if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.ContraindicationsГиперчувствительност ь (incl. other derivative azola), simultaneous terfenadina or astemizola.Side-EffectsFor part of the intestine : nausea, pain in the abdomen, diarrhoea, flatulence, Gepatotoksicnosti.so the skin : skin rashes, fatigue Stevens-Johnson, toxic It'sa Nekroliz.prochie : headache, convulsions, lakopenia, thrombocytopenia, alopecia; Of the liver / kidney and modification of the blood (in patients with weakened immune), anaphylacticskie reaction.Patient interactionIncreases T_1/2 of plasma gipoglikemicakih oral drugs (derivatives sulfonylureas), the concentration fenitoina, rifabutin, alone in the blood. When coupled with the admission varfarinom increased protrombinovoe time (12%), with rifampitsinom reduces AUC (25%) and T_1/2 of plasma (20%), with cizapridom-increased risk of cardiovascular violations, including Evolution paroxizmalna ventricular tachycardia.OverdosingTreatment : High diurez, symptomatic therapy.PrecautionsWhen signs of drug hepatotoxicity should be abolished.Dosing and AdministrationInside. Adults with kriptokokkovh infections in the first day, 400 mg, to 200-400 mg once a day, the duration of therapy depends on the course of the disease, with kriptokokkovom meningitis at least 6-8 weeks, for the prevention of cryptococcal meningitis in AIDS patients to 200 mg / day, the long-term. In kandidemy, disseminirovannom 4-8 and other forms of invasive kandidozhnykh infections in the first day, 400 mg, followed by 200 mg / day; Orofaringealnom at 4-8, 50 mg / day for 7-14 days, in patients with a marked decline in immunity is a more long-term, for the prevention of AIDS-150 mg once a week; atroficescom in 4-8 of the oral cavity associated with wearing dentures : 50 mg once a day for 14 days, and other infections kandidozhnykh mucous membranes (except genital) : 50-100 mg / day for 14-30 days; in waginalnom 4-8 : 150 mg once, to reduce the frequency of relapse-150 mg once a month, the duration of treatment is determined individually at 4-12 months; in kandidoznom balanite : 150 mg once; mikoze to 4-8 and skin : 150 mg once a week or 50 mg once a day, treatment duration 2-4 weeks (up to 6 weeks); otrubevidne with psoriasis : 300 mg once a week for two to three weeks (under single reception 300-400 mg), or 50 mg once a day over a period of two to four weeks; in onihomicose : 150 mg once a week, up to the replacement of the infected nail; in the deep endemic mikozah : 200-400 mg / day, the duration of therapy is Individuhalno.detam daily every night with 4-8 mucous membranes to 3 mg / kg / day, the first day possible 6 mg / kg; generalizovannom at 4-8 or cryptococcal infection : 6-12 mg / kg / day, for the prevention of fungal infections in children with reduced immunity : 3-12 mg / kg / day; in children with impaired kidney daily dose should be reduced. Newborn children up to two weeks of life is normal dose, but at intervals of 72 hours, 2-4 weeks of life, with an interval C.u 48 patients with renal failure by a single admission dose adjustment is not required to admit kursovom-dose shock front mg, Cl with creatinine of more than 50 ml / min, 100% of the recommended dose, and Cl creatinine less than 50 ml / min, 50% of the recommended dose; patients in gemodialise-one dose after each dialysis.Storage conditionscaps. : In dry the dark place at a temperature of no higher than 30 ° CShelf lifecaps. : 3 and |
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