Griseofulvin

Chemical name

(1'S-транс)-7-Хлор-2',4,6-тр��метокси-6'-метилспиро [бензофуран-2(3H),1'-[2]цик логексен]-3,4'-дион

Gross

C17-H17-Cl-O6

Characteristics

White or white with a yellowish sheen crystalline powder to a specific (mushroom) smell. Nerastvorim water, little soluble in alcohol.

Of drugs

The drugs-antimycotic (fungistaticescoe). Suppress fusion protein (link to Matrix RNA), in violation of a cell wall (hitinsoderjath mushrooms) and mitoticescoe division fungal Kletok.horosho absorbed in the intestine, fungistatical concentration in the blood is achieved in 4-5 hours T_1/2-20 p.m. Selectively accumulating in rogovom layer of the skin and its pridatkah and in the liver, adipose tissue, skeletal muscular. Biotransformation occurs in the liver. Provided with urine and Kalom.vazavaet stunting different types dermatomicetov : trihofitona, mikrosporuma, epidermofitona.

Indications

Favus, and trihofitia mikrosporia nails of the head and smooth skin, epidermofitia smooth skin onihomikozy.

Contraindications

Hypersensitivity, porfirinova disease gepatozellliarnaya failure, malignant neoplasms, lakopenia, blood diseases, pregnancy, breast-feeding (at the time of treatment should stop breastfeeding).

Side-Effects

Nausea, vomiting, diarrhea, pain in epigastralna area parestesia limbs, dizziness, the spatial orientation, agranulozitos, lakopenia, kandidozny disease, allergic reactions (skin rashes, swelling Kwinke).

Patient interaction

Do proximity effect anti-reduces-oral contraceptives. Fungistaticescuu activity reduces barbiturates.

Precautions

Be wary appoint the гиперчувствительност и to penitsillinam, gipokoagulih conditions, as well as patients whose professional activity requires quick reactions and increased attention.

Dosing and Administration

Inside, at the time of delivery. Daily dose for adults is 500 mg, for children from 21 to 22 mg / kg The course of treatment : the defeat nails skin of the head on 4-6 weeks, the bodies of 2-4 weeks and feet-4-8 weeks, his hands at least four months, his legs not less than six months. The highest daily intake, and one Locally, liniment are thin layer in a daily dose of not more than 1930

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