Irunin

Roman name

Irunine

The composition and the form of

1 capsule contains intrakonazola 0.1 g; in a contour acheikova packing 10 or 15 pc. , in a cardboard bundle one package.

Of drugs

Antimycotic. Ingibiruet synthesis ergosterola cell membranes mushrooms.

Pharmacokinetics

For high biodostupnostthew (lowered to pochern-pechenocna failure and AIDS and neutropenia after organ transplantation). C_max achieved in 3-4 hours, the time of the equilibrium concentration in plasma with long-term use of 1-2 weeks. Equilibrium concentration in the admission 100 mg drug once a day - 0.4 µ g / ml; To the reception of 200 mg once a day, 1.1 µ g / ml, 200 mg twice a day-2 µ g / J Associated with the plasma protein at 99.8%. Itrakonazola concentration in the lungs, kidneys, liver, bones, stomach, spleen, skeletal muscle 2-3 times higher than the concentration in plasma; In the tissues containing keratin, four times. Therapeutic итраконазола concentration in the skin maintained for a period of 2 to 4 weeks after the end of four weeks of treatment. Therapeutic concentration in keratine nails achieved through one week after the start of treatment and maintained for a period of six months after the three-month treatment. Low concentrations determined and sebaceous glands port skin. Metabolised in the liver with the formation of active metabolites. Return plasma dwuhfazoe, T_1/2-half days. Excretion kidneys within 1 hour (35% in the form of metabolites; 0.03% in unmodified form) and the intestine (3-18% in unmodified form).

Farmakodinamika

Net antimycotic of a wide spectrum of activity. Derived триазола. Active against dermatomycosis (Trichophyton spp. , Microsporum spp. , Epidermophyton floccosum), yeast fungus Candida spp. (including C.albicans, C.glabrata, C.krusei), mould fungi (Cryptococcus neoformans, Aspergillus spp. , Histoplasma spp. , Paracoccidioides brasiliensis, Sporothrix schenckii, Fonsecaea spp. , Cladosporium spp. , Blastomyces dermatitidis).

Indications

Mycobacterium skin, mouth, eyes, a tropical avium; Vulvowaginalny kandidomikoz; Onihomikoz due dermatofitami and / or yeast; Aspergillez system, kandidomikoz, kriptokokkoz (incl. chriptokokkovi meningitis), gistoplazmoz, sporotrihoz, parakoktsidiomikoz, blastomikoz, otrubevidnyi zoster.

Pregnancy and lactation

Not recommended during pregnancy : found in pilot studies that Itraconazole is the development of the fruit. Credible clinical data to substantiate the safety of the itrakonazola rights, in the period are not available. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, simultaneously ingesting terfenadina, astemizola, cizaprida, midazolama or triazolama.

Side-Effects

For part of the intestine : neuralgia, nausea, pain in the abdomen, anorexia, vomiting, constipation, hepatitis, increasing transaminaz Pecheni.so the nervous system and sensory organs : headache, dizziness, peripheral нейропатия.Аллергиче��кие reactions : skin itching, urticaria, ангионевротический swelling, Stevens syndrome - Джонсона.Со the urogenital system : дисменорея, отечный syndrome, urine staining in the dark цвет.Прочие : алопеция.

Patient interaction

Inductive mikrosomalnogo oxidation in the liver (rifampicin, phenytoin) reduces bioavailability itrakonazola, inhibitors zitohroma CYP3A4 (ritonavir, indinavir, klaritromicin) increasing its bioavailability. Enhance and prolong the effect of drugs metabolism which is the type of enzymes zitohroma 3A (terfenadin, astemizol, cizaprid; Midazolam, triazolam (for oral admission), the proximity combined, ciclosporin A, digoxin, a BAC digidropiridina, quinidine, takrolimus and vincristine). Antacids drugs reduce suction itrakonazola (interval between admission to two hours). Together with the admission of drugs metabolism which is the type of enzymes zitohroma R450 3A aggravating and / or lengthening effects. There are encouraged to nominate at the same time as terfenalinom, astemizolom, cizapridom, midazolam (for the reception inside), triazolam, hinidine, pimozidom, simwastinom, lovastatinom. Together with the application of indirect антикоагулянтами, ritonavir, indinavir, saquinavir, бусульфаном, доцетакселом, триметрексатом, alkaloids rosy periwinkle, циклоспорином A BAC (дигидропиридин, verapamil), рапамицином, такролимусом, дигоксином, карбамазепином, буспироном, алфентанилом, алпразоламом, мидазоламом (in / in), рифабутином, метилпреднизолоном may change their levels in the blood plasma, effects and side effects. Therefore, it is necessary to control the level of these drugs in plasma, and, if necessary, dose reduction. Together admission itrakonazola with zidovudine, fluvastatinom, etinilestradiolom or noretisteronom meaningful interactions have been noted.

Precautions

In patients with impaired immunity (AIDS, the following organ transplantation, neutropenia), might require an increase in dose. Patients cirrhosis of the liver and / or kidney failure, with high transaminaz plasma blood Itraconazole appointed under the control of plasma, and only when the expected effect of therapy over possible risk of liver damage. The length of the admission of more than one month should control the liver. During treatment for women of child-bearing age are encouraged to use contraceptives.

Dosing and Administration

Inside, immediately after delivery, capsules With the Zelikom.pri vulvowaginalnom kandidamikoze-200 mg twice a day for one day or 200 mg once a day for 3 days; Otrubevidne with psoriasis and 200 mg / day for 7 days; Dermatomikozah with, 4-8 of the oral cavity is 100 mg once a day for 15 days. The impact of skin wrists and feet have additional treatment in the same dose for 15 days; In gribkovom keratite-200 mg once a day for 21 days; onihomicose to 200 mg / day for 3 months or refresher courses on the 200 mg twice a day for one week, followed by intermittent. The impact of nails in the feet (regardless of the defeat nails on the hands) have three days of treatment for one week, at intervals of three weeks. The impact of nails on the hands of a two days of treatment for one week, at intervals of three weeks. The systems aspergilleze-200 mg / day for 2-5 months; If necessary, increase the dose to 200 mg twice a day. The systems 4-8, 100-200 mg once a day for 3 weeks to 7 months; If necessary, increase the dose to 200 mg twice a day. The systems chriptokokkoze without signs of meningitis and 200 mg once a day supporting therapy, which is 200 mg once a day, the duration of treatment, ranging from 2 months to 1 year. In kriptokokkovom meningitis-200 mg twice a day. In gistoplazmoze-initial dose of 200 mg once a day, increasing frequency reception to 2 times a day for 8 months. In sporotrihoze-100 mg once a day for 3 months or 6 months when parakoktsidioidoze; In hromomicose - 100-200 mg once a day for 6 months; in blastomikoze from 100 mg once a day to 200 mg twice a day for 6 months.

Storage conditions

caps. : List B. In dry the dark place at a temperature of no higher than 25 ° C

Shelf life

caps. : 2 grams.

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