Ketoconazole

Chemical name

цис-1-Ацетил-4-[4[[2-(2,4-ди��лорфенил)-2-(1H-имидазо��-1-илметил)-1,3- диоксолан-4-ил]метокси ]фенил]пиперазин

Gross

C26-H28-Cl2-N4-O4

Of drugs

The drugs-antimycotic (fungicidal) antiandrogennoe. Synthesis stops ergosterola, triglycerides, and phospholipids required for the synthesis of cell walls of fungi (fungi their ability to form yarns and Colonies), in violation of permeability cell wall. The ingestion well drawn (especially in the acidic environment of stomach). Bioavailability is directly related to the size of the dose. C_max achieved in 2 hours Associated with the protein, cell. Dynamics concentration in the blood is described bieksponencialna curve. Is enter spinnomozgovu liquid. Is oxidative O-desauxilirovaniu, oxidation degradation and aromatic gidrauxilirovaniu. T_1/2 is 2-4 hours Provided, unedited, and in the form of active metabolites, 4 days to return 70% of the amount (57% from faeces, 13% from urine). Active against dermophytes drojjepodobnykh fungi kind Candida and molds, causing systemic mycosis. Ingibiruet androgenov education, effective in the treatment of certain forms of gormonozawisimah prostate cancer.

Indications

Mikozy skin, hair and nails caused by dermatofitami and / or yeast (dermatofitos, onihomikoz, kandidoznaya paronihia, multicolored corporis, tinea, trihofitii) mikozy blood, mikozy eye disease leishmaniasis, seborainey dermatitis, dandruff, systemic mikozy (candidiasis, parakoktsidiomikoz, gistoplazmoz, koktsidiomikoz, blastomikoz) gribkovi sepsis, vaginal candidiasis; Mikozy in patients with immune deficiency (HIV).

Restrictions on the use of

Reducing the crust napochechnikov and glands, severe kidney and liver failure.

Contraindications

Hypersensitivity, severe liver disease, pregnancy, breast-feeding (should stop breastfeeding).

Side-Effects

Nausea, vomiting, diarrhoea, chronic hepatitis, tranzithornoe raising transaminaz in blood, headache, dizziness, drowsiness, fotofobia, ginekomastia, reduced libido, oligospermia, hair loss, allergic reactions (urticaria, skin itch, artralgia, parestesia, hyperthermia, etc.).

Patient interaction

Ters effect amfoteritina B. Incompatible with terfenadine, astemizolom, alcohol. Antatsida, holinolitiki, H_2-blokatora significantly reduce intake, rifampicin and isoniazid-concentration in the blood. Ingibiruet mikrosomalnoe oxidation at the same time appointed drugs and increases their concentration increases difenina toxicity. Impact stimulate kortikotropina the adrenal glands. The simultaneous appointment of oral contraceptives with low hormone was bleeding.

Dosing and Administration

Inside, at the time of delivery, adults and children weighing more than 30 kg to 200 mg once a day, the ineffectiveness of 400 mg once a day; Children weighing 15 to 30 kg, 100 mg once. The preventive use in patients with immune deficiency shall adult 400 mg / day, children from 4 to 8 mg / kg / sut. Cream cuticles affected areas once a day. Intrawaginalno-1 supp. within 3-5 days. Treatment is still less than a week after the disappearance of symptoms.

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