Miconazole

Chemical name

1-[2-(2,4-Дихлорфенил)-2-[(2, 4-дихлорфенил)метокси] этил]-1H-имидазол (and in the form of nitrate)

Gross

C18-H14-Cl4-N2-O

Of drugs

The drugs-antimycotic, Sun. Stops biosynthesis ergosterola shell membranes plazmaticakih mushrooms alters lipid composition and permeability of cell walls. The most sensitive dermatomiceta and yeast. Effective in pathology caused by the Coccidioides immitis, Cryptococcus neoformans, Petriellidium boydii, Paracoccidioides brasiliensis, Candida albicans, Trichophyton, Epidermophyton, Malassezia furfur, some grampolaugitionami Bakteriami.pri local drive in the blood found only a small number of metabolites. Quickly down in the liver, with a system with urine excreted 14-22% dose in the form of inactive derivatives. Farmakokineticeski profile three T_1/2 with 0.4, 2.1 and 24.1 hours for each of the phases. Gistogematicalkie barriers facing bad. In spinnomozgovu liquid barely penetrates.

Indications

Fungal (trihofitia and epidermofitia hands, feet and torso, skin candidiasis, a multicolored zoster, etc.) and mixed грибково-бактериальн��е skin and nails, blood candidiasis, rotoglotocny candidiasis and prevention in the treatment of inhalants glukokortikoidami, vulvowaginale kandidozy and infections caused by grampolaugitionami microbes.

Contraindications

Hypersensitivity, herpes virus, pregnancy (II and III trimenon), a children's age (up to 12 years).

Side-Effects

Local skin reactions (burning, pricking, red), irritation of mucous membrane vagina, pain in the bottom of the abdomen, allergic contact dermatitis.

Precautions

We recommend caution in the appointment during lactation (better at the time to refrain from breast-feeding), diabetes, circulation violations. The impact of nails to cut them as short as possible. Particular attention has been paid to handling mejpaltsevykh spacing to defeat feet; Shown wearing free, well provetrivaema shoes and a change of socks at least once / den. Effective treatment of vaginal losses can be used only if simultaneous therapy sexual partner. It should be borne in mind that the use of Donin mikonazolom less reliable mechanical contraception (latekssoderjaschie means : condoms, vaginal diaphragm). The local reactions, or lack of clinical improvement within four weeks of calls for treatment and further examination. There is a need to avoid falling cream in the eye.

Dosing and Administration

Locally, the cause wamyten with soap and clay to the skin and gently rubbing the affected areas twice a day, morning and evening. The course continues until the complete disappearance of symptoms and in the next few days to avoid a relapse. Normal Course duration-Ned.intrawaginalno 2-6, 1 supp. at night for a 6-7 Dnei.naruzhno, causing a small amount of cream to the depressed area vulva or enter the vagina, the course of seven days. Gehl appointed to 1 / 2 teaspoons dose (1 lojecke-124 mg miconazole) four times a day is recommended for as long as possible to delay gel in the mouth. In onihomikozah liquid to be affected fingernails and environmental their skin with a special brush twice a day and cover occluzionna bandage, a treatment long before vrastania nogteva new plates.

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