Naftifine

Chemical name

(E)-N-Метил-N-(3-фенил-2-пр��пенил)-1-нафталинмета��амин (as hydrochloride)

Gross

C21-H21-N

Of drugs

The drugs-antimycotic. Violate biosynthesis sterolov the inhibition skvalen-2 ,3-epoksidasy. Reduces number sterolov, especially ergosterola forming part of the cell wall of fungus (fungizidnaya activity), or to the accumulation of skvalena cell (fungistatical activity). Fungizidno acting dermatofita - Trichophyton (rubrum, mentagrophytes, tonsurans), Epidermophyton spp. (floccosum), Microsporum (canis, audouini, gypseum), mold fungi Aspergillus species and pathogens sporotrihoza. At drojjepodobne mushrooms kind Candida, including Candida albicans, depending on the particular strain-fungizidno or fungistaticeski. It has antibacterial properties against grampolaugitionah and gramotricationah microbial pathogens are mixed infections. Locally reduces inflammatory reactions and itching. Particularly effective in the treatment of mycosis volosistah of body and skin гиперкератозом.Прони��ая rogove in layers of skin, a sufficient concentration to suppress growth dermatomycosis. After application on the skin 1% gel or cream systemic absorption was 4.2, or 6% of the substances respectively. Vsosavcheesa number is biotransformation (part), and excreted in urine and faeces; T_1/2 approximately 2-3 days.

Indications

Fungal defeat smooth skin and nails of the head (epidermofitia major skin wrinkling and feet, especially by Epidermophyton floccosum, trihofitii, including those caused by Trichophyton rubrum and mentagrophytes, mikrosporia, kandidozy skin otrubevidnyi zoster, etc.); Onihomikozy; Mikozy to secondary bacterial infection.

Contraindications

Гиперчувствительност ь (incl. to propilenglikolu for solution benzilovomu alcohol for cream), opened rot surface (for the solution), pregnancy, breast-feeding (at the end of treatment), children's age.

Side-Effects

Local reactions : stinging sensation, and erythema (gel, cream, solution), taste (cream, solution), inflammation (cream, solution), irritation (cream), and skin sensitivity to nadavlivanii (gel).

Precautions

Is naruzhno only. It should avoid the mucous membranes of eyes, nose, mouth, etc. can be in the open wounds (especially solution). Patients warned banning tobacco smoke casts or wrap the affected surfaces without consulting a doctor. If you have signs of irritation or гиперчувствительност и Terms treatment.

Dosing and Administration

External. Is in the form of cream (1%) or solution (1%). In dermatomikozah - are thin layer of sufficient quantity and thoroughly scrub massages movements (cream) in the depressed area and adjacent areas of skin, previously treated and dried once a day over a period of two to four weeks; Kandidozah with not less than four weeks; Where appropriate course postpone until 6-8 weeks. In the absence of clinical improvement after 4 weeks of use to clarify diagnosis. In onihomikozah-cream or solution are two times a day for the depressed area, serving heavy bandage Course six months; With complications forms-to eight months. To prevent a recurrence of treatment continue for a further two weeks after clinical improvement.

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