Natamycin

Chemical name

Stereoisomer 22-[(3-амино-3,6-дидезокси -бета-D-маннопиранозил )окси]- 1 ,3,26-тригидрокси-12-мети л-10-оксо-6,11,28-триоксат��ицикло[22.3.1.0/5,7/] �ктакоза-8,14,16,18,20-пента ен-25-карбоновой acid

Gross

C33-H47-N-O13

Characteristics

Powder white or cream-coloured nerastvorim in water. Дэвида in glacial acetic acid and dimethylformamide, weak in metilovom alcohol. Sensitive to light.

Of drugs

The drugs-antimycotic. Is tetraene (containing four double bonds in the molecule linear type). In all cases, yeast (Torulopsis and Rhodoturola) and drojjepodobnykh fungi (Candida), dermatomicetov (Trichophyton, Microsporum, Epidermophyton), as well as other pathogenic fungi (Aspergillus, Penicillium, etc.). No impact (in vitro) for gram and gram bacteria. Is creating a set of components sterolovykh membranes fungus violates its permeability and is his lysis (fungizidnyi effect). There is a systemic action, as not absorbed from the digestive tract, from the surface of the skin and mucous membranes. Using vaginal plugs under the influence of body temperature formed foaming mass, which contributes to equitable distribution natamitina eye on the shell.

Indications

Fungal diseases of the skin and mucous membranes, including acute and psevdomembranosny atroficski candidiasis against cachexia and immune deficiency, as well as after treatment with antibiotics, and korticosteroidami zitostatikami; Otomikozy, exterior otita (including primary and acute kandidozom); Candidiasis skin, nails and ulcers; Waginita, vulvita, vulvowaginita, balanopostita, mainly due to Candida mushrooms; Dermatomikozy.

Contraindications

Гиперчувствительност ь.

Side-Effects

The ingestion, nausea, vomiting; In the local-light irritation and stinging sensation.

Specific guidance

During menstruation is not recommended to use waginalnami candles. It should be borne in mind that ethanol, which is part of the vaginal plugs can cause reaction гиперчувствительност и.

Precautions

With persistence during waginitov caused by Candida albicans, in addition taken on one table. four times a day for 10 to 20 days (for the rescue center kandidozna infection in the gut), and cream for the treatment of kandidoznogo defeat genitals partner.

Dosing and Administration

Inside, adults in the 4-8 bowel-100 mg four times a day for one week; Children on the 100 mg twice a Sutki.pri dermatomikozah (incl. kandidozy skin, nails, oprelosti children) cream are depressed at the surface one or more times a day, in otomikozah-oxidative agent one or more times a day (before the sample ear, and after a transfer to the department turundu passage of cotton or wool). In balanopostite-cream to be affected skin areas once or more than once a day. With the disappearance of the symptoms of treatment are encouraged to continue a few more Dnei.pri waginitah, vulvowaginitah intrawaginalno-100 mg (1 supp.) Within 3-6 days (suppository entering of the vagina, while in the rest, as far as possible once a day, at night). During menstruation treatment interruption. With persistence during waginitov-take more pills (1-4 times daily for 10-20 days), and use the cream 4-8 genitals partner. During treatment it is not necessary to exclude sexual contacts.

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