Nystatin

Chemical name

A mixture of stereoisomers nistatina A-1, nistatina A-2 and other nistatinov

Characteristics

Antibiotics polienova structure. Light powder to a specific smell. Bitter taste. Virtually nerastvorim in water, very little in alcohol. Gigroskopichen. Broken by the action of light, high temperature, oxygen air solutions acids and alkalis.

Of drugs

The drugs-antimycotic (fungistaticescoe, fungicidal). There is in the structure of a large number of double bonds, leading to higher troponosti substance sterinovm entities zitoplazmaticescoy membranes mushrooms. As a result, the molecule integral membrane in cells with the formation of multi-channel approach to the uncontrolled transport water, electrolytes and nonelectrolytes. Box loses resistance to external osmoticeskih forces and stabilizing. After intake of nystatin little absorbed in the digestive tract and the rezorbtivoe not Vrajeno.akteven against drojjepodobnykh fungus Candida and aspergilla. Provides fungistaticescoe and, in high doses, fungicidal effect. Tolerance to nistatino sensitive mushrooms growing very slowly.

Indications

Tumours mucous membranes mouth, genitals, stomach, skin.

Contraindications

Hypersensitivity, the liver, pancreatitis, a disease hospital of stomach and duodenal ulcers, pregnancy.

Side-Effects

Diarrhoeal events (nausea, vomiting, diarrhoea, pain in the abdomen), allergic reactions : skin itching and skin, fever, chills.

Dosing and Administration

Adults : 500,000 U inwards 3-4 times / sutki. Daily dose ranging million U, in the most severe cases, 4-6 million Ed.detam : up to 1 year, 100,000 U, from 1 to 3 years, 250,000 U 3-4 times per day, over 13 years in the 250000-500000 U 3-4 times per day. The course of treatment is 10 to 14 days. If necessary, repeat the course in 2-3 Ned.waginalno : on the 250000-500000 U twice a day. Ointment applied on the surface of infested twice / sutki.

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