Oxiconazole

Chemical name

(Z)-1-(2,4-Дихлорфенил)-2-(1H -имидазол-1-ил)этанона 0 -[(2,4-дихлорфенил)метил ]оксим (in the form of nitrate)

Gross

C18-H13-Cl4-N3-O

Characteristics

Almost white crystalline powder. Rat in methanol, weak in ethanol, chloroform and acetone, it is very very low in the water.

Of drugs

The drugs-antimycotic. Ingibiruet biosynthesis ergosterola increases the permeability of cell walls and oslablet its barrier function. Fungiziden against pathogenic fungi (Epidermophyton floccosum, Trichophyton mentagrophytes, and rubrum, etc.), bakteritiden to Staphylococcus spp. , Corynebacterium.cerez 5 h after the addition of the skin creams in the dose of 2.5 mg / cm ^ 2 concentration in the epidermis is 16.2 xylose, and in the superficial layer rogovom 3.64 xylose, in the deeper layers of 1.29-xylose. System adsorption rate is very low (after application 150g cream oxiconzol in the serum is not defined). Nevertheless, the 0.3% rate shown in the urine within 5 days after a single  application (cream).

Indications

Dermatomikozy (including soles, and smooth surfaces nails body), caused by susceptible strains.

Restrictions on the use of

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy and breast-feeding.

Side-Effects

Local reactions : itching, burning, pricking (cream, solution); Irritation, allergic contact dermatitis, tinea, reddening skin cracks, mazeration, filling in the form of bubbles and fridge (cream); Grilling, pinching, pain, disgidrotical eczema (solution).

Precautions

Avoid contact with eyes. When side effects or lack of clinical improvement treatment ceased. There is a need to bear in mind the possibility of a negative impact on the ability of fertilnuu.

Dosing and Administration

Nakozhno at night. Shoe to be infected and nearby areas 1-2 times a day. Duration : 2 weeks, with the skin mikozah body, 1 month when mikozah feet and for a further 1-2 weeks after complete recovery to prevent recurrence.

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