Terbinafine

Chemical name

(E)-N-(6,6-Диметил-2-гептен -4-инил)-N-метил-1-нафтал енметанамин

Gross

C21-H25-N

Characteristics

White or no melkochristalliceski white powder dissolves easily in methanol and metilenhloride, soluble in ethanol, it is difficult soluble in water.

Of drugs

The drugs-antimycotic (fungicidal). Provides effect on dermatofita, drojjepodobne and mold fungi. It is striking zitoplazmaticalkie membranes fungal cells specific ingibiruet skvalenepoksidazu and violates ergosterina synthesis, resulting fungizidnyi effect. Active for almost all fungi pathogenic to humans, but above all else, the red trihofitona (minimum inhibiting concentration is 0,001-0,06 µ g / ml), and pathogenic yeasts, molds, and pitiriazisa mizelialnah forms of Candida.bystro absorbed in the digestive tract. The effect of a "material is about 40%. C_max-1 µ g / ml, reached after 2 h after administration of the dose of 250 mg. In sossoudistom with almost entirely (99%) associated with plasma proteins. Passes gistogematicalkie barriers and relate to the fabric; High concentrations accumulate in the body (including the sebaceous glands and hair folliculah) and the subcutaneous tissue. Is expressed epidermo- and onihotroponostthew. The second day after taking 250 mg concentration in rogovom layer of skin grows 10 times on the 12th day in 70 times. The speed of diffusion exceeds the growth rate nail. T_1/2 terminal phase of the 400 hours Before excretiei is biotransformation education inactive metabolites. About 70% of the dose appears in the urine. In single coil 100 l cream on the surface of the skin area of 30 cm ^ 2 in the urine found 3.5% Dozy.pri onihomikozah case treatment efficiency is 95%, with onihomikozah feet-more than 90%. Effective in the mould mikozah, trihofitii, rubrofitia, epidermofitia with multiple onihomicose. As a cream applied to intertriginoznom mikoze feet and wrists, rubrofitia smooth skin and raznotsvetnom inhabitants. Disease is the 75 to 95% of patients chronically dermatofitiami smooth skin. Treatment of patients with progressive kandidozom smooth skin and defeat large and mejpaltsevykh folds, and vulvowaginitom paronihiami caused Candida albicans resistant to medication nistatinom, levorinom combined with klotrimazolom and mikonazolom leads to the mental age of day, and a full settlement process, in 3-5 weeks; in the absence of recurrence within 12 months.

Indications

Fungal damage to the skin, nails and hair, candidiasis the skin and mucous membranes.

Contraindications

Hypersensitivity expressed pechenern-kletocnaya and kidney failure, blood diseases, cancer, metabolic, pathology receptacles limbs, pregnancy, breast-feeding (at the end of treatment), children's age (up to 2 years).

Side-Effects

Feelings gravity and pain in epigastralna field, the taste, a decline of appetite, nausea, diarrhoea, holetaz, neutropenia, thrombocytopenia, skin allergic reactions; Stinging feeling, skin redness and itching of the skin in the area of creme.

Specific guidance

Delete records drop in the treatment onihomikoza wrists and feet for six weeks is required.

Patient interaction

Gistaminove H_2-blokatora increase plasma concentration (biotransformatia suppress). Terfenadin reduces and rifampicin twice increases Cl.

Precautions

In raznotsvetnom vital effectively only local application system appointed onihomicose justified in the case of total destruction of most of nails, the express podnogtevogo giperkeratoza, inefficiency prior local therapy. In the treatment process (two weeks and at the end) need to be processed protivogribkovu shoes, socks and hosiery. Expressions of the kidney or liver makes lower doses. Avoid falling cream on the mucous membrane of the eyes, nose, mouth.

Dosing and Administration

Inside, the food once a day in the evening dose of 250 mg or two times a day, 125 mg. Shoe cause morning and / or night on the skin infested previously purified and podsushennouu, and the surrounding areas. The average length of the course to defeat skin-1-2 weeks, drop-shock 3-6 months. Children set dose, depending on body weight.

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