Alpisarin

Chemical name

2-C-бета-D-(Глюкопираноз ид)-1,3,6,7-тетраоксиксан тон

Characteristics

Melkochristalliceski powder from the yellow to greenish white to yellow to greenish white or brown to dark brown in colour, without smell or with weak smell. Virtually nerastvorim in ethanol-water, chloroform, little slowly soluble in the mixture acetone - water (1:1).

Of drugs

Drugs, the antiviral, antibacterial (bacteriostatic), immunomodulirutee, противовоспалительно е. Ingibiruet reproduction Dnk-soderjath viruses (Herpes simplex 1 and 2 type Herpes zoster, Varicella zoster, to a lesser extent, MP and HIV). Induces products gamma-interferon blood cells. Suppress growth grampolaugitionah and gramotricationah bacteria, the simplest and M. Tuberculeza.pri long-term use (3 months) in adults and young developing laboratory animals in doses exceeding therapeutic in 10, 50 or more times, the drug caused violations of functional liver and kidneys. With the doses of 100 and 500 mg / kg, exceeding recommended for people 10 to 50 times in the stomach rats from 1 to the 19th day of pregnancy drug has embriotoksicescoe Actie.pri ingestion rapidly absorbed from the digestive tract. S_max achieved after 1-3 hours It penetrates the cells and tissues (liver, kidney, heart, spleen), in 12 hrs detected in small numbers in the tissues of the brain. Linking blood protein, 70-90%. Excreted kidneys and digestive tract.

Indications

Infections of skin and mucous membranes caused by the virus Herpes simplex, Herpes zoster and Varicella zoster : genital herpes, simple herpes, chickenpox, herpes zoster, gerpetiformnaya s eczema, red flat zoster, warts, condylomata HPV.

Pregnancy and lactation

Contraindicated in pregnancy.

Contraindications

Hypersensitivity, pregnancy.

Side-Effects

Allergic reactions.

Dosing and Administration

Inside, regardless of the meal, adults and children over 12 years of 0.1-0.2 g 3-4 times daily for 5 to 10 days; Children 6-12 years, 0.1 g 2-3 times a day; Children 1-6 years in the 0.05-0.1 g 2-3 times per Sutki.mestno, 5% ointment applied on the affected areas of skin without the bandages two or three times a day. 2% ointment on the mucous membranes. The course of treatment is 10 to 30 days. The course Povtoriaut.ostraya and retidivirutaya form simple act extra localization and single-vsapaniah are at home against 2-3 times a day for three to five days. In the case of vsapani as well as a fever, limfadenopatii-inside and in the form of materials for 5-14 Dnei.gerpetiformnaya eczema s in a comprehensive therapy for 7-21 days. Genital herpes - 2% ointment applied on the affected areas 4-6 times a day for 7 to 10 days, during retidiviruuschem disease more inside during 5-14 Sut.virusnye disease mucous membranes of the oral cavity, inside and cause the infection looks 2% ointment for 5-15 days, erosivno-azvennaya form of a flat red depriving mucous membranes of the oral cavity, for a 2-4 Ned.zabolevania caused by the Varicella zoster - combination therapy, including oral, and the local application of 2% (children) and 5% (adults) at the ages hit home for 5-21 days. Preventing recurrence-oral course after one month after the end of treatment and then mejrecidivee periods courses for 10 to 14 days.

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