Cridanimod

Chemical name

Sodium 10-метиленкарбоксилат- 9-акридон

Of drugs

The drugs-immunomodulirutee, antiviral. Immunostimulating the induction of interferon synthesis. Increases ability клеток-интерферонопр��дуцентов develop interferon induction in the pathological agent (property is maintained long after the drug), and a body high captions endogenous interferonov identified as early alpha and beta. Activates stem cells from bone marrow, eliminates the imbalance in the cell subpopulation with activated effector T links immunity and macrophages. Against the backdrop of malignant diseases increases activity of natural killernah cells (from products interleikina-2) and normalizes synthesis Necrosis Factor tumors. It stimulates the activity of white polimorfnoyadernah (migration, cytotoxicity, phagocytosis). Has antiviral (for RNK- Dnk-genomble and viruses) and antihlamidiinoe Actie.posle intramuscular injection material exceeds 90%. S_max plasma (in the range of doses of 100-500 mg) recorded in 30 minutes and is accompanied by increases in the concentrations of whey interferon (reaches 80-100 IU / ml plasma dose of 250 mg). Easily passes through gistogematicalkie barriers. Report the news, more than 98% in unaltered, T_1/2-60 min. Activity induced interferonov after reaching a peak gradually decreases and reaches baseline values at 46-48 C.pri Injecting animals a different doses 40-50 times the recommended human therapeutic dose had revealed deaths. Study Chronic indicative of a lack of adverse effects on the cardiovascular, nervous, digestive, respiratory, excretory, blood and other systems of the body. Mutagenna activity in tests on animals, cultures, cells and bacteria have been detected. There is damaging action on the sex cells. Embriotoksicski tertogennogo and is not detected.

Indications

Prevention and treatment инфекционно-воспалит��льных diseases correction Immunodeficiencies Control and immunostimulirutaya therapy : news, including influenza (severe); herpes infection (Herpes simplex, Varicella-zoster) various sites (heavy primary and retidivirute forms); viral encephalitis and encephalomyelitis; hepatitis (A, B, C, the acute and chronic forms, including during recuperation); Zmw-infectia against immunodeficiency syndrome; hlamidiina, ureaplazmennaya, mikoplazmennaya infection (Baby, epididimit, prostate, zerwitzit, salpingit, hlamidiina limfogranulema); kandidoznae and �актериально-кандидоз ные infections (skin, mucous membranes and internal organs); multiple sclerosis; cancer; deficiency (radiation acquired and congenital oppression synthesizing interferon).

Restrictions on the use of

Children's age (safety and efficacy of the children are not identified).

Pregnancy and lactation

When pregnancy and breast-feeding is possible if the expected effect therapy outweighs the potential risk to the fetus and newborn.

Contraindications

Hypersensitivity, severe kidney and heart failure, giperimmunny fulminantna version of acute viral hepatitis, auto-immune diseases.

Side-Effects

Allergic reaction; Subfebrilitet accompanied by lomotoy in joints; In the m-a local fast passing pain at the injection.

Patient interaction

Ters effects of immunosuppressive drugs.

Precautions

Treatment should be under the supervision of a physician and with the monitoring of immune status. In rejecting that subfebriliteta NPVS reception. To reduce local pain and should enter with 2 ml bessolevy novokaina solution. To apply caution in patients with chronic intensity in the past vCJD infectious processes (combined with antibiotics). When treating chlamydia used in conjunction with ftorhinolonami.

Dosing and Administration

V / m, 250 mg (4-6 mg / kg). Treatment course 5-7 injection for 10-15 days every 48 hours; Where necessary, in case the dose of 500 mg every 36 hours (dose rate depends on the nature of the disease). Inside, 30 minutes before the food with liquid, 6 tablets (0.75 g) through 48 h 5 times (in the 1st, 3rd, 6th, 9th and 12th day of treatment).

Literature

Bashmakov NV, Glazkova L.K., Motornuk JI, al S.Yu. The health of newborns from mothers with urogenital chlamydial infection : the effectiveness of rescue and rowamiqinom neovirom during беременности/Материа��ы Republican scientific-practical conference "Healthy Newborn : perinatal problems and forecasting, Russia, Yekaterinburg, 20-22 November 2000

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