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Synthetic anti funds
The groupThis team brings together sulfanilamida (see Sulfanilamida) derivatives ftorhinolona (see Fluoroquinolones), as well as naftiridina, hinolina and nitrofurana : nalidiksova acid (nevigramon, Blacks), acid oksolinova (gramurin) pipemidovaya acid (palin, pimidel), various 2-deriwata- 5-nitrofurana (see Other synthetic antibacterial means). Most are highly antimicrobial activity, the details of which are still not fully explored. Partly due to the effect of the blockade polymerization, and hence the suppression of DNA synthesis in sensitive bacterial cells. Applied these drugs mainly with infectious diseases urinary tract infections, stomach, etc.
The synthetic antibacterial compounds are derivatives imidazola with antibacterial and protivoprotosana protivogribkova activity (clotrimazole, ketokonazol, miconazole, etc. The antiprotosanam product of this group is metronidazole, widely used for the treatment of trichomoniasis, and amebiaza and other protozoal diseases; to the same group are tinidazol, nitazol (nitrotiazolnoe derivative), and some other substances. tumours also has high activity against anaerobic bacteria. Recently discovered metronidazole activity against Helicobacter pylori, infections, playing a role in the pathogenesis of ulcer disease stomach and duodenal ulcer. In conjunction with specific drugs protivoyazvennami (ranitidine, omeprazol, etc.) metronidazole are used to treat the disease.
Most of the specific anti-tuberculosis drugs, including antibiotics (aminoglikozida, ansamitina) are included in this group. Agent tuberculosis is fast (kislotoustoytchiv) opened R. Koch why it is often referred to as "stick figures". " Specific chemotherapy (with the election zitotoksicnostthew) TB drugs divided into 2 groups : a) drugs I stimulants (the republic); b) preparations II series (reserve). The drugs I consider a gidrazid izonicotinova acid (TB) and its derivatives (gidrazona), antibiotics (streptomycin, rifampicin), PASC and its derivatives. The drugs II series are ethionamide, protionamid, ethambutol, cycloserine, pyrazinamide, tioazetazon, aminoglikozida - kanamycin and florimitsin.
Most anti-tuberculosis drugs suppress reproduction (bakteriostaz), and reduce the virulence of Mycobacteria. Drugs in high concentrations has bactericidal action. For sustained therapeutic effect and prevent possible recurrence of TB drugs are long-term. The drugs and the duration of their application depend on the form of tuberculosis and its currents, the previous treatment, sensitivity M. tuberculosis to malaria, his endurance, etc.