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The groupSulfanilamida were the first химиотерапевтическим и (systemic) antibacterial means, which have been used widely in the practice of medicine. With the advent of penicillin and other antibiotics, and more recently ftorhinolonov, their use has decreased somewhat, but the drugs in this group are not lost and, in some cases, to be appointed in infectious diseases, by sensitive to the micro-organisms. Sulfanilamida suppress growth grampolaugitionah gramotricationah and bacteria, some of the simplest (causing malaria, toxoplasmosis), Chlamydia (at trahome, paratrahome). Their effect is mainly due to a violation of education necessary for the development of micro-organisms and folate digidrofolata, in the molecule responsible para-aminobensanaya acid : sulfanilamida close chemical structure to para-aminobensana acid They seized microbial cage instead para-aminobensana acid, and thus violate the its metabolism.
The timing circulation in the body after a single reception sulfanilamida divided into four groups : a) a short-acting (streptozid, norsulfazol, etazol, sulfadimezin, etc.); b) secondary action (sulfazin, etc.); c) Long-Acting (sulfapiridazin, sulfamonometoksin, sulfadimetoksin, etc.); d) sverhdlitionogo actions (sulfalen etc.). Almost a year of the period led to the emergence of a large number of microbial strains resistant to sulfanilamidam. Overcoming resistance to combining with sulfanilamida trimetoprimom. Last ingibiruet дигидрофолат-редукта��у and inhibits transforming emerging microbial cell (despite the presence sulfanilamidov) digidrofolieva acid in the form of kofermentnuu - tetragidrofolievu, blocked transfer odnouglerodistah fragments in the synthesis and purinov pirimidinov, resulting in a violation of RNA and DNA. A highly effective combination therapies containing sulfanilamida combined with trimetoprimom (see Protivomicrobnye in combinations). Of sulfanilamidnykh products of the system are currently being widely used ko-trimoksazol (bactrim, biseptol) sulfadimetoksin, sulfalen, sulfapiridazin, mafenid, etazol, salazopiridazin.
The chemical structure to sulfanilamidam rather close the so-called sulfones (diafenilsulfon, solusulfon, diucifon, etc.) They are all running against lepers fast and applied for the treatment of leprosy.