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The groupFluoroquinolones-derivatives 4-hinolona containing the seven hinolinovogo kernel nezameshchenny or pieperazinovy replacement cycle and the 6-fluorine atom. Connections of this group (norfloksacin, pefloksacin, ofloxacin, ciprofloxacin, lomefloksacin, etc.) are active antibacterial means, and recently has been widely used in medical practice.
All ftorhinolona active against gramotricationah aerobic bacteria to the most sensitive strains of staphylococcus (streptococci more resistant); degree of sensitivity and sustainability depends on the type of bacteria and characteristics of a drug.
The mechanism of action ftorhinolonov particular importance is the impact on metabolism DNA bacteria. These compounds inhibit Dnk-girazu (Class topoizomeraz), which manages the structure and function of DNA in the bacterial cells. The blockade has resulted in the loss of bacteria (bakteritidnyi effect). Do not rule out the impact of the ftorhinolonov RNA bacteria and bacterial synthesis of proteins, on the stability of membranes and other life processes bacterial cells.
Key testimony Directions : urinary tract infections, acute respiratory infections (with flora GRAM), infections caused by salmonella and Shigella, osteomielit, prostate, infections caused by Pseudomonas.