Directory Antineoplastic funds Alkilirute funds
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Alkilirute funds

The group

One of the therapy as a means of derivatives бис-(бета-хлорэтил)-ам��на. Response to the use of these compounds have the ability to nitrogen mustard, or trihloretilamina, expressed concern lakopeniu aplaziu and bone marrow. In clinical practice, the less toxic derivatives бис-(бета-хлорэтил)-ам��на (ziklofosfan, hlorbutin etc.). Following the бис-(бета-хлорэтил)-ам��нами received cytotoxic compounds alkilirute other chemical groups : etielenimina, 78-53-5 acids, triazena, drugs platinum, nitrozomocevina et al.
In the derivative actions бис-(бета-хлорэтил)-ам��на as alkilirute substances which form kovalentne the nuclephiliic compounds, including such biologically important groups, as phosphate, aminne, sulfgidrile, imidazole, etc. Zitotoksicescoe of these and other compounds alkiliruth is primarily due to the molecular structure of DNA (purinov, pirimidinov) and RNA (to a lesser extent), to the detriment of living cells and blocked their mitoticescoe division. High sensitivity to these substances have the nucleus of cells giperplazirovannah (malignant) tissue and limfoidna tissue.
Etielenimina mechanism of close to the derivative бис-(бета-хлорэтил)-ам��на. They blocked mitoticescoe dividing cells through education lateral links between chains DNA, which prevents its replication. Use of these drugs as a result of new therapy drugs in the past, a few narrowed. Of derivatives etielenimina the application is tiotepa.
The antitumoral of platinum derivatives (carboplatina, tsisplatina) is the ability to bifunktionalnomu alkylated thread DNA leading to a prolonged suppression of the biosynthesis of nucleic acids and cell death.

Drugs

  • Bendamustine
  • Benzotef
  • Busulfan
  • Carboplatin
  • Carmustine
  • Chlorambucil
  • Cisplatin
  • Cyclophosphamide
  • Dacarbazine
  • Dibrospidium chloride
  • Dipin
  • Fotemustine
  • Fotretamine
  • Hexaphosphamide
  • Ifosfamide
  • Imiphos
  • Lomustine
  • Lophenalum
  • Melphalan
  • Nimustine
  • Nitrosomethylurea
  • Oxaliplatin
  • Paphencyl
  • Phtorbenzotheph
  • Procarbazine
  • Prodimin
  • Prospidium chloride
  • Sarcolysin
  • Temozolomide
  • Thiotepa
  • Aksiplat
  • Alkeran
  • Benzotef
  • Benzotef injection 0.024 g
  • Biknu
  • Blastocarb
  • Blastolem
  • Vero-ifosfamid
  • Vero-tiofosfamid
  • Vero-tsisplatin
  • Gexafosfamid
  • Dacarbazine
  • Dacarbazine lahema
  • Dacarbazine medak
  • Detizen
  • Dipin
  • Dipin liofilizirovanny injection 0.02 g
  • Imifos
  • Imifos injection 0.05g
  • Imifos for injection 50 mg
  • Ifosfamid sterile
  • Ifosfamid-lans
  • Carboplatin, west delta
  • Carboplatin-teva
  • Carboplatin-ebeve
  • Kemocarb
  • Kemoplat
  • Ledoksina
  • Lakeran
  • Lomustin
  • Lomustin medak
  • Lofenal
  • Lofenala tablets 0.3 g
  • Metinur
  • Mielosan
  • Mielosana pills 0.002 g
  • Mileran
  • Mustoforan
  • Natulan
  • Nidran
  • Nitrozometilmocevina
  • Oncoplatin
  • Paraplatin
  • Pafenzil
  • Pafenzila pills 0.025 g
  • Platamin
  • Platidiam
  • Platimit
  • Platin
  • Platin liofilizirovanny injection
  • Platinol
  • Prodimin
  • Prodimina tablets 0.1 g
  • Prospidin
  • Prospidin liofilizirovanny for injection 0.1 g
  • Prospidina ointment
  • Sarkolizin
  • Sarkolizina pills 0.01g
  • Spirobromin
  • Spirobromin liofilizirovanny for injection 0.1 g
  • Temodal
  • Tiotepa-tioplex
  • Tiofosfamid
  • Fautrin
  • Fautrin injection 0.02 g
  • Ftorbenzotef
  • Ftorbenzotef injection 0.04 g
  • Hlauxiperazin
  • Hlorbutin
  • Hlorbutin pills
  • Holoksan
  • Zikloplatin
  • Cyclophosphamide
  • Ziklofosfan
  • Instant Ziklofosfan-lans
  • Ziklofosfana tablets covered liner 0.05g
  • Tsisplatil
  • Cisplatin
  • Liofilizirovanny cisplatin injection 0.01g
  • Tsisplatin-teva
  • Tsisplatin-ebeve
  • Zitoksan
  • Zitoplatin
  • Zitostazan
  • Eloxatin
  • Endoksan