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Antineoplastic hormonal and hormone antagonists
The groupAs a means of therapy with gormonalnozawisimah tumours (mostly) apply several agonists and antagonists androgenov, estrogen, gestagenov.
Estrogens appointed to suppress the body androgenov (for example, in prostate cancer cancer), androgena, on the contrary, - to reduce the level of estrogen (with breast cancer, etc.). When breast cancer or cancer of the uterus are also progestina (медроксипрогестерон) .
By antiandrogenam identified a number of compounds and steroidna nesteroidna structures to suppress physiological activity of endogenous androgenov. Their actions related to competitive blocking receptors in androgenov tkaniah-misheniah - biosynthesis and secreta androgenov they do not violate. Antiandrogennoe the share to a greater or lesser degree, a number of endogenous steroid compounds, including progestinam, oestrogens and their synthetic derivatives, as well as certain derivative androgenov themselves. In the 1970s, there have been reports of high activity antiandrogenna steroid compounds derived carboxianilida (flutamida etc.). Antiandrogena applied mainly in cancer prostate gland. Assign them to the states giperandrogennah women (girsutizm, hair, etc.) and the children (with early sexual maturation).
A special type of activity antiandrogenna have connections ingibirute 5-alfa-reduktazu - vnutricletocny enzyme prostate, help transform testosterone into a more active androgen-digidrotestosteron (DGT).
Some drugs (aminoglutetimid) specifically inhibit the secretion of adrenal glucocorticoids (cortisol), and are therefore in a Itsenko - Kushinga etc. Glukokortikoida in connection with their limpoliticski action and the ability to oppress mitosis cells used in acute leikozah (mainly for children) and limfomah malignant.
The mechanism of hormonal differ from cytotoxic therapy funds. The main role is to restore damaged gumoralna regulation of cells. The possibility is not excluded, and special effects on tumor cells : they are, to some extent, prevent cell division and promote their differencirovke.