Directory → Antineoplastic funds → Antineoplastic hormonal and hormone antagonists → Aromazin
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АромазинSee also ExemestaneRoman nameAromasinPharmacokineticsAfter intake of rapidly absorbed, C_max achieved within 2 h, has been associated with the plasma protein by 90%, T_1/2 about 24 hours, easily penetrates the tissues. Inaguiruetsa oxidation of methylene groups in the position in June with the participation of izofermenta CYP 3A4 and / or rehabilitation 17-ketogroup альдокеторедуктазами . Provided, incl. in the form of metabolites in urine (unchanged to less than 1% of dose) and spread over one week.Clinical pharmacologyReduced estrogen concentrations in the plasma of women in postmenopause is the dose of 5 mg and reaches its maximum (more than 90%) at doses of 10-25 mg. The patients in постменопаузе with breast cancer under the influence of dose of 25 mg ароматазы activity is reduced by 98%.IndicationsBreast cancer among women postmenopause (natural or induced), advanced against antiestrogenami therapy, steroid inhibitors aromataza or progestinami.Pregnancy and lactationContraindicated.ContraindicationsHypersensitivity, the children's age.Patient interactionЭстрогенсодержащие drugs nullify effects.PrecautionsNot recommended for women in predmenopause. Postmenopausny status to the definition of source, and opened seconds.Storage conditionsThe temperature does not exceed 30 ° CShelf life3 yearsThe registration011835/01-2000The drug formsToday, dvoyakovpuklae pill white with a slight sheen serovatam Sugar-coated diameter of about 6 mm, with the inscription in the form of numbers in 7663 carried out by the black print painted on one of the parties. |
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