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Bicalutamide

Chemical name

{+}-4'-Циано-альфа,альфа, альфа-трифтор-3-[(п-фто��фенил)сульфонил]-2-мет ил- m-lactootoluidid

Gross

C18-H14-F4-N2-O4-S

Characteristics

The white crystalline powder. Virtually nerastvorim water, poorly soluble in chloroform and alcohol, it is difficult soluble in methanol, soluble in acetone.

Of drugs

The drugs-antiandrogennoe, protivoopujolevoe. Communicating with androgenovmi receptors on the surface of cells organov-misheni makes them inaccessible to androgenov by increasing the concentration of hormones in the blood plasma. Once inside quickly and completely absorbed (food is not affected by the completeness removals). The blood plasma protein binds to 96%. Treated stereospecificescoy biotransformation in the liver. Not S-enantiomer, glukuronidiruetsa and quickly withdrawn from the body. Active R-enantiomer also be glukuronidace education metabolita inactive. T_1/2 is about 7 days. Excreted kidneys and jelchew in equal ratios.

Indications

Cancer prostate gland.

Restrictions on the use of

Violation of the liver.

Contraindications

Hypersensitivity, the children's age, contraindications women.

Side-Effects

Severe strokes, hypertension, heart failure, cough, pharyngitis, bronchitis, pneumonia, rhinitis, diarrhoea phenomenon xerostomia, gastric bleeding, melena, anxiety, depression, reduced libido, drowsiness, nervousness, male, mialgia, arthritis, apnoea bogies muscles limbs, contracture, pain in the chest, diabetes, poliuria, dizuria, urine retention, swelling, fever, sweating, allergic reactions.

Patient interaction

Do indirect effects anticoagulants.

Dosing and Administration

Inside, regardless of the meal. Adults - 1 table. (50 or 150 mg) once.

See also

All products of this group