Buserelina acetate

Roman name

Buserelini acetas

Of drugs

Priced products gonadotropinov, гонадотропин-рилизин�� hormone analogue, reduces the secretion luteinizirutego hormone, reduces the secretion �олликолостимулирующ��го hormone, reduces the secretion androgenov and estrogen, zitostaticescoe, protivoopujolevoe, a treatment for endometriosis, castriratee pharmacologically.

Pharmacokinetics

In intra application buserelina acetate completely absorbed by the mucous membrane of the nose. In small amounts allocated to breast milk. T1/2 is about 3 hours

Clinical pharmacology

Completely absorbed in the intranasal application. In small quantities secretiruetsa in breast milk.

Indications

Endometriosis (pre - and post-treatment), mioma uterus, giperplasticskie the endometrium, infertility (for the reproduction).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : headache, mood lability, insomnia, Deprescia.so the urogenital system : Reduce Yeah, flushes, vaginal dryness, menstrualnopodobnoe haemorrhage (rarely). Allergic reactions : urticaria, hyperemia skin, irritation of nasal mucous membrane, angioneuroticeski Otek.prochie : rash, pain at the bottom of the abdomen, active bleeding (rare).

Patient interaction

Together use hormonal contraceptives or other drugs sex hormones may develop syndrome giperstimulyatsii ovaries.

Overdosing

Currently, the cases of drug overdose Buserelina acetate were reported.

Precautions

Prior to the start of treatment to rule out a pregnancy in the first two months of therapy adequate contraception. Be wary appoint patients with depression (It should be a doctor). In the initial stage of treatment may develop ovarian cyst. The patients who use contact lenses, there may be signs of eye irritation. Using the backdrop of rinita vspryskivaniem to clean bow moves. Again treatment is possible only after an assessment of the ratio of expected benefits and potential risks of osteoporosis and comes after medical examinations under dynamic hormonal control and Uz-monitoringom.

Dosing and Administration

Intranasal in the treatment of endometriosis, uterine mioma, giperplasticeskih the endometrium 0.9 mg / sut. Daily dose should be equal portions to 1 vspryskivaniu in each of the bow three times a day at regular intervals (6-8 hours a day in the morning, afternoon and evening). Treatment started on the 1st or 2nd day from the beginning of menstruation. When treating infertility using assisted reproduction 0.6 mg per day since mid-luteinova phase of menstrual cycle (with a 21-24 day cycle) to the day of NMG. The daily dose being equal portions to 1 vspryskivaniu forward progress four times a day at regular intervals. When expressed against the reproductive system and the "weak" response to ovarian stimulation superovulation drugs gonadotropinov daily dose can be reduced to 2 vspryskiwanyi a day or increase dose gonadotropinov.

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