Cyproterone

Chemical name

(1бета,2бета)-6-хлор-1,2-д��гидро-17-гидрокси-3'H-ци клопропа[1,2]прегна-1,4,6- trien-3 ,20-dion (and in the form of 17-azetta)

Gross

C22-H27-Cl-O3

Of drugs

The drugs-antigonadotroponoe, progestagennoe, antiandrogennoe, protivoopujolevoe (zitostaticescoe). Competitive androgenne blocking receptors in kletkah-misheniah reduces androgenov level in the blood. The ingestion completely absorbed (bioavailability is about 100%). C_max blood-in 3-4 hours T_1/2 from 3-4 hours to 2 days. After the / m introduction (bioavailability-100%) C_max in plasma through 1-3 days; T_1/2 to 4 days; Equilibrium concentration in plasma set after four injections. Accumulating in the adipose tissue. Up to 30% drug and its metabolites extracted through kidneys, and 70% in the liver, 0.2% of maternal Molokom.u men reduces unhealthy sexual attraction reduces potency, protects presentatelnuu iron from androgenov. Is healing skin acne and prevents new acne, reduces high salootdelenie nails on the head of the skin, reduces hair loss on the head and excessive growth on the face and other parts of his body. Oppressing secretion gipofizom gonadotroponogo hormone (the central), and inhibits ovulation, which makes contraceptive effect.

Indications

Men-gipersexualnosti, neoperabelnaya carcinoma of prostate cancer. The women expressed phenomenon androgenization.

Contraindications

Diseases of the liver (12:00 syndromes-Johnson, fell, tumors), tromboamboliceski syndrome, depression, sickle cell anaemia, jaundice idiopathic pregnant, herpes pregnant, pregnancy, breast-feeding (a non-breast-feeding).

Side-Effects

The change in mass of the body, anxiety, fatigue, depression, decreased ability to concentrate, the liver (in high doses). Men-suppression spermatogeneza, ginekomastia. For women is the feeling of tension in the mammary glands. In a rapid-cough, shortness of breath.

Precautions

During the period of treatment needed to be monitored as the liver, napochechnikov crust, the composition of peripheral blood. The diabetes mellitus recommended correction dose of insulin or other saharosnijath drugs. For women before treatment should be deleted pregnancy. During treatment should refrain from taking activities requiring greater attention.

Dosing and Administration

The mode set individually depending on the disease. Cancer prostate cancer : in / m (excludes intravazalnoe introduction), 300 mg every 1-2 weeks, the interior for the 100 mg 1-3 times a day. Lower doses and lifting treatment Postepenno.lechenie produce symptoms androgenization women : inwards to 10 mg 1st to the 15th day cycle (in combination with Diana-35).

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