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Divigel

See also Estradiol

Roman name

Divigel

The composition and the form of

1 g gel on the basis of alcohol contains seconds 0.001g; in the bags of aluminum foil to 0.5 g or 1 g, in a box 28 or 91 pc.

Pharmacokinetics

Trancdermalnoe causing drug in the dose of 1.5 mg a concentration in the blood plasma of 340 pmol / O Bioavailability-82%.

Farmakodinamika

Coupled with medroksiprogesteron acetate reduces total cholesterol without affecting the content antiaterogennah Alfa-lpvp.

Indications

Climacteric syndrome (with natural or artificial menopause); Primary prevention of osteoporosis.

Pregnancy and lactation

Divigel is contraindicated for the treatment of pregnancy and lactation.

Contraindications

Hypersensitivity, uterine bleeding unclear etiology, embolic violations; Estrogenzawisimy cancer (including breast or cervical); Severe liver disease; Syndromes Dabina-Johnson or agitators; Pregnancy, lactation.

Side-Effects

Swelling, increased body mass index, headache, bloating mammary glands, changing face, vnezikliceskie uterine Krovotechenia.redko : enhancing AD, migraine, a change drive, mood changes, diarrhoea events (nausea, vomiting, stomach cramps), irritation of skin.

Specific guidance

In intaktna womb to the consistent appointment gestagennah preparations for the 14 days from the 12th day of the gel (because of the risk of developing cancer of endometrium).

Precautions

With frequent injury may menstrualnopodobne uterine bleeding; If the patient had forgotten scheduled to gel and has been in place for less than 12 hours, there is a need to do so immediately. If it's been more than 12 hours, causing delay to the next application.

Dosing and Administration

External and in a systematic manner or cyclically dose selected individually from 0.5 to 1.5 g gel (0.5-1.5 mg seconds) per day, is a daily, one on the skin bottom of the front wall of the abdomen, the inner surface of thighs or buttocks (in an area of palm 1-2).

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

3 years

The registration

015526/01

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