Estrogens conjugatate

Of drugs

Drugs, the mode. Regulate development and maintenance of the female reproductive system, the formation of secondary sexual characteristics. Facilitate or kupeeroout of menopause syndrome - vazomotorne disorders, emotional (irritability, anxiety, depression) and urogenital (atroficski vaginitis, progressive diffuse atrophy external genital organs) symptoms. Prevents development postmenopauznogo osteoporosis, increase LPVP reduces certainty - and the overall cholesterol, reduces the risk for cardiovascular заболеваний.Компонен��ы drug soluble in water and is absorbed in the digestive tract are infiltrating target tissue (genitals, breasts, bones, Wikipedia, Gray), and zitoplazmu nucleus of cells, which stimulate the synthesis of RNA and protein. Biotransformation occurs mainly in the liver estrogena withdrawn from jelchew but reabsorbiruyutza of bowel and returned to the gantries wrists. Water estrogen compared with the acid ionisiruyutza properties in the body and kidney removed with a minimum of reabsorption in the bone.

Indications

Climacteric syndrome (flushes, night sweating, sleep disturbance, irritability, anxiety, depression, atroficski vaginitis, progressive diffuse atrophy external genital organs), estrogennaya deficiency during menopause and postmenopauza, postmenopausny osteoporosis, dysfunctional uterine bleeding, cardiovascular disease during menopause and postmenopauza, gipogonadizm for women post ovarioektomii, primary lung cancer, cancer neoperabelny prostate gland.

Contraindications

Hypersensitivity, breast cancer or suspected it (except neoperabelland) estrogenzawisimae tumours, intensive tromboflebita or embolism, a breach of the kidneys and liver, sickle cell anemia, prolonged immobilization, 12:00 syndromes, and Johnson fell, vaginal bleeding unclear etiology, pregnancy and breast-feeding.

Side-Effects

Depression, headache, increased body mass index, giperplazia endometrium, the increase in pain and breast предменструальноподо бный syndrome, swelling, changes of the liver, jaundice, rashes, and pigment spots on the face, the irritations contact lenses, contact allergic reactions.

Patient interaction

Poorly effect acetylcholinesterase inhibitors, anticoagulants, antidepressants, protivodiabeticakih funds. Rifampicin, barbiturates, butadion up estrogen metabolism.

Overdosing

Symptoms : nausea, vomiting, breeding Krovotechenie.lechenie : washing stomach supporting therapy.

Precautions

The caution (under constant surveillance) Designate diabetes, epilepsy, mastopatii, distributed EMG, tireotoxicose, porfiriah. Long-term use of estrogen may increase the likelihood of developing cancer endometrium; To reduce the risk giperplasticeskih changes endometrium used in combination with gestagenom from 10 to 14 day monthly cycle.

Dosing and Administration

Inside. For cyclic application-0,625-1,25 mg / day; Preravista therapy : 21 per day, with an interval of 7 days, and then re-continuous treatment-day every day. In vazomotornah symptoms - 0.625 mg / day, atroficskih waginitah and progressive diffuse atrophy external genital organs - 0,3-1,25 mg / day, osteoporosis, 0.625 mg daily (permanently or broken). After ovarioektomii and primary ovarian dysfunction, 1.25 mg / day or continuously cycles in gipogonadizme women for 2.5-7.5 mg / day for 20 days from 10-dnevnami breaks with dysfunctional uterine artistic methods for 3.75-7.5 mg / day for 20 days (in the past 10 days, coupled with gestagenom). In neoperabelnom breast cancer-10 mg / day for 3 months, with neoperabelnom cancer prostate gland 1,25-2,5 mg three times a day.

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