Fosfestrol

Chemical name

(Е)-4,4'-(1,2-Диэтил-1,2-этен диил)бис[фенол]бис[диг идрофосфат] (and in the form of tetranatrieva salt)

Gross

C18-H22-O8-P2

Characteristics

White or white with kremovatam melkochristalliceski white powder soluble in water, nerastvorim in alcohol.

Of drugs

Drugs, the mode. Solid contact with the receptor zitoplazmaticakimi sex hormones, it hinders the androgenov effects in patients with androgenzawisimami neoplasticescimi processes (adenocarqingoma prostate gland). This leads to a slowdown in the growth of primary tumours and inhibits cancer in the bones. Rapidly absorbed. Metabolised in the liver, most secretiruetsa jelchew in intestine, which is reabsorbtion (or withdrawn from faeces), a fraction of the allocated memory.

Indications

Adenocarqingoma (incl. metastezirutaya) prostate cancer (palliative care), lack of estrogenna functions.

Contraindications

Tumours breast estrogenzawisimae neoplasticskie processes defeated liver, and tromboflebita embolism.

Side-Effects

Induction neoplasticeskih development of sexual organs (women), the liver, increased jelchnokamenna disease tromboembolia, hypertension, reduced tolerance to glukoze, gipercalziemia increase and compaction mammary glands, diarrhoea phenomenon holetsaticeski hepatitis, headache, dizziness, depression, edema, changes in body mass index, allergic skin rashes.

Dosing and Administration

Pain 50 mg three times a day, if necessary dose can be increased; Maximum daily intake - 1 and B / in introducing 0.5-1 g of substance divorced in 250-300 ml of 0.9% solution of sodium chloride at a speed of 20 to 30 drops / min for a period of five days. Then moving towards supporting oral therapy.

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