Leuprorelin

Chemical name

6-D-Лейцин-9-(N-этил-L-про��инамид)-10-деглицинами д-лютеинизирующий �ормон-рилизинг-факто�� (swine)

Gross

C59-H84-N16-O12

Of drugs

The drugs-antigonadotroponoe, antiandrogennoe, antiestrogennoe, protivoopujolevoe. Interacts with the receptor in gonadorelina gipofize is their short-term stimulation followed desencitizaciei long. Reversible oppressing secretion and LG opened reduces testosterone levels in men and seconds from the Jenshchin.posle / m injections during the first 7 days of sex hormones raised (physiological response), the 21-28 day-dropping : testosterone for men to castratingo level seconds from the women to the level of postmenopause or ovarioektomii. Subsequent monthly supports a low sex hormones in the blood, a setback gormonozawisimah neoplasms (cancer prostate, uterus fibromioma) cures endometriosis. The return of physiological secretion in Gormonov.pri / m injections released from the copolymer for 1 mo. Bioavailability of 98% for men and 75% for women. T_1/2 - 3h In small, but measurable amounts circulates in the plasma of more than 30 days after the last injection.

Indications

Gormonozawisimy advanced cancer prostate cancer (as an alternative to blindness or estrogenterpii) fibromioma uterus (in the pre-period or the surgical treatment), endometriosis (laparoscopiceski confirmed).

Contraindications

Гиперчувствительност ь (including the ones �онадотропин-рилизинг �ormona) gormononezawisimy cancer prostate cancer, uterine bleeding unclear etiology, kidney failure, pregnancy, breast-feeding, old age.

Side-Effects

Nausea, vomiting, diarrhoea or constipation, blood surges to a person increased sweating, a violation hearing and vision uproar in the face, parestesia, headache, depression, anxiety, increased fatigue, a sense sdavljenia chest, ECG changes, the decrease libido, dermatitis, itchy skin, rashes; For men, impotence, ginekomastia, reducing inflammation, women, vaginal dryness, vaginitis, furniture, skin, girsutizm, lowering the density of bone tissue and bone mass, increased cholesterol in the plasma Krovi.mestnye reaction, pain and redness at the injection. After the first introduction of a period of 7 days may be temporary effects : for men increased symptoms, pain in the joints, there is a breach of urination, muscle weakness in legs, the women bleeding.

Patient interaction

Alcohol potenziruet slowdown in the rate of emotional reactions.

Overdosing

It has increased by Effectov.lechenie : symptomatic.

Precautions

Patients with a high risk of complications to be under medical supervision for a period of 7 days after the first injection. During treatment, it was necessary to monitor the LDG, transaminaz and prior to the re-rate the bone density. For women of childbearing age before the therapy should be deleted pregnancy, used to negormonale contraceptive methods, the first injection for the third day menstrual cycle. It should be borne in mind that, after months of renewed tension after 3 months. Impact speed psychomotor reactions, and during the course of treatment is not recommended for the potentially dangerous types of Deatelnosti.mesto be changed every month (buttocks, thigh).

Dosing and Administration

B / m (injection are ex tempore) every four weeks : if cancer prostate 3.75, or 7.5 mg, in fibromiome uterus and endometriose 3.5 mg; Course is not more than 6 months.

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