Lynestrenol

Chemical name

(17альфа)-19-Норпрегн-4-е��-20-ин-17-ол

Gross

C20-H28-O

Of drugs

The drugs-progestagennoe. Treated with a specific receptor zitoplazmaticakimi, swyazawatisa with hromatinom kletok-mishenei and modifying synthetic processes in the cell. The move mucous membrane of the uterus phase proliferation in secretornuu phase. Suppress ovulation, a yellow body and lengthens the time of menstruation (with the extended admission). Increases viscosity cervical mucus. Is weak androgenne Swoystwa.bystro and is absorbed in the digestive tract. Time to C_max is about 3 hours Treated biotransformation. Pharmacological activity of the metabolite - norethisterone. Excreted primarily Mochoe.pri long-term use as an oral contraception reduces the risk of inflammatory diseases of the small pelvis, iron-deficiency anaemia, reduces the likelihood of fibrosno-kistosna mastopatii, ovarian cancer and endometrium, incl. endometrium cancer. Protective action depends on the length of contraception and maintained for a period of five years after the end of the reception (antenatal women is not less than 10 years).

Indications

Dysfunctional uterine bleeding, amenorea (primary or secondary), oligomenorea, endometriosis, endometrium carcinoma, mastopatia, pre syndrome, delaying normal ovulation. Oral contraception during lactation and protivopokazannosti estrogen.

Contraindications

Serious liver, uterine bleeding unspecified etiology, itching, porphyria, otoscleros, heart failure, arterial hypertension, depression, trombofilicescie state vnutripechenochny holetaz, congenital malformations of cium, insulinzawisimy diabetes, pregnancy, including ectopic (in history).

Side-Effects

Bleeding "breakthrough" or mazhushchie separated from the genital tract, girsutizm, hloazma, changing face, nausea, diarrhoea, headache, dizziness, anxiety, depression, pain in the chest, increased body mass index, lower tolerance to glukoze change in level cium, transaminaz, protrombinovogo index lipoproteidnyi profile genital candidiasis, skin, itchy skin.

Patient interaction

Barbiturates, rifampicin, laxatives to reduce the effectiveness of contraception. Macrolides increase the risk of toxic shock liver. Increases plasma concentration бета-адреноблокаторо�� and cyclosporine.

Overdosing

Symptoms : nausea and Rvota.lechenie : symptomatic.

Precautions

With long-term use requires periodic monitoring of blood coagulability of lipid and hydrocarbons exchange, the cium, transaminaz. The reception limit fats, carbohydrates (cakes), which is particularly important for women, with a higher baseline body mass index. The trend of hypertension should be monitored AD (reduce liquid to 1.5-2 litres a day), with insulinzawisimom diabetes-glycolic profile (may require increased doses of insulin). In the case of dysfunctional uterine bleeding in women of reproductive age treatment should start after лечебно-диагностичес��ого vulva cancer. Inefficiency hormonal therapy (relapses bleeding and giperplasticeskih the endometrium) requires clarification causes bleeding. The long delay menstruation amidst therapy should be excluded ectopic pregnancy. It should be borne in mind that the reliability of contraception significantly reduced the irregular employment, as well as vomit and diarrhea.

Dosing and Administration

Inside. In endometriose, dysfunctional uterine artistic methods, 5-15 mg / day long course (at least 6 months). In predmenstrualnom syndrome, 5 mg / day with the 14 to 25 day cycle. In endometrium carcinoma, 30 to 50 mg per day. In amenoree usually appointed after estrogenna the endometrium of 5-10 mg / day in the second half of the cycle. In order to contraception, daily, from 1 to 28 day cycle for the 0.5 mg / day at the same time.

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