Nilutamide

Chemical name

5,5-Диметил-3-[4-нитро-3-(т рифторметил)фенил]-2,4-��мидазолидиндион

Gross

C12-H10-F3-N3-O4

Of drugs

The drugs-protivoopujolevoe, antiandrogennoe. Competitive blocking cell receptors androgenov violates tying digidrotestosteron and prevents its biological effects in organah-misheniah, incl. in the tumour cells prostate gland Cancer slowing growth. The one-time admission effect is not less than 24 hours

Indications

Cancer prostate cancer (in a combination therapy), antiandrogennaya preparations for the airlift operation to change sex from men.

Contraindications

Hypersensitivity, anaemia, the liver, lung diseases, child.

Side-Effects

Giperventilatia, pain while breathing, limiting breathing, interstiziale changes in the lung of appetite and bowel functions, nausea, vomiting, pastosnosti wrists and ankles, pain in the lower divisions of the hands and feet, visual disorders (particularly weakened adaptation to darkness), the sense of tidal, smoking, signs of liver function (skin itching, dark urine, jaundice, pain in the right part of the torso, grippopodobnyy syndrome, raising cium and transaminaz) anaemia.

Patient interaction

Do effect fenitoina, propranolola, hlordiazepoksida, lidocaine, diazepam, theofillina.

Precautions

In developing human respiratory function dose reduction or elimination from the market. Treatment should be discontinued when the clinical and laboratory signs of toxic to liver and controlling pain, which is the ankle. During therapy should abandon admission alcohol can "disulfiramova reaction" (heart, malaise, nausea, vomiting). To improve light-adaptation to wear glasses with tinted windows. The driving of vehicles on the course of treatment.

Dosing and Administration

Inside, squeezed more liquid, in a daily dose of 300 mg (two sessions); The 4 hour daily dose reduction to 150 mg (1 reception).

Literature

MA ML, Filov VA, Akimov MA, Akimov AA Introduction to farmakoterapiu malignant tumors-St. : SOTIS, 1999-1989.

Directory → Antineoplastic funds → Antineoplastic hormonal and hormone antagonists → Nilutamide