Progesterone

Chemical name

Pregn-4-en-3 ,20-dion

Gross

C21-H30-O2

Characteristics

The white crystalline powder. Virtually nerastvorim in water, soluble in alcohol, it is soluble in vegetable oils.

Of drugs

The drugs-progestagennoe. Is hormone yellow body. Contact with the receptor on the surface of cells Organs, enters the nucleus DNA activates and stimulates the synthesis of RNA. Promotes transition mucous membranes of the uterus in coagulation secretornuu phase creates the necessary conditions for the implantation of a fertilized egg, reduces the sensitivity of the uterus to oksitotino and relaxes the muscles (tokolitik). Activates growth secretonego atinusov the mammary glands and induces lactation; Proteinlipazou stimulates increases reserves fat increases levels bazalnogo and induced insulin, glucose utilization, the accumulation in the liver glycogen, a concentration is gipoazotemia and azoturiu; Increases (in small doses) or suppressing (large) products gonadotroponah pituitary hormones. The tissues breast blocks blood capillaries, reduces swelling (cyclical) soedinitionotkanna stroma hampered proliferatiou and mitoticescuu activity cancer ERCP (with the application of the gel). In all the way (except , in the form of gel) is rapidly absorbed. C_max when administered achieved after 1-3 h with intrawaginalna software through 2-6 hours The binding protein with the plasma of about 90%. The liver becomes predominantly 3-alfa, 5-beta-pregnandiol (pregnandiol). Excreted in the urine in the form of glukuronidov and pregnandiola.

Indications

Solution, capsules : hormone replacement therapy (amenorea, dismenorea, menopause and perimenopauzalny period, infertility, nedonashivanie pregnancy girsutizm, endometriosis, cancer of the uterus, breast, prostate, IVF fertilization, contraception, diagnostics secreta Estrogenov.gel : mastodinia, mastopatia.

Restrictions on the use of

Bronchial asthma, heart failure, hypertension, abnormalities in the kidneys, central nervous system diseases including depression, epilepsy, migraine; diabetes mellitus, giperlipidemia, ectopic pregnancy, breast-feeding.

Contraindications

Hypersensitivity, tumors of the breast and reproductive system, the functions of the liver, vaginal bleeding of unknown genesis, the propensity to trombozam, acute or trombophlebitis thromboembolitic diseases, incomplete abortion, porphyria expressed human liver (capsules for the reception inside).

Side-Effects

The ingestion : drowsiness and dizziness, disorders menstrual cycle (decrease intermediate bleeding). Injections : tromboembolia (including pulmonary artery and cerebrovascular diseases), throm, pulmonary veins retina, galactorea, calkulezny holetsistit, holetsaticeski hepatitis, lethargy, drowsiness, suffering, impaired vision, anorexia, changes in body mass index, oedema, girsutizm, alopecia, increased mammary glands, allergic reactions, pain at the injection.

Specific guidance

The treatment reduced the concentration of attention (to be careful when driving vehicles).

Patient interaction

Do bromokriptina effects and systemic coagulants reduces anti-.

Dosing and Administration

Inside, in / m intrawaginalno, Mestno.pri amenoree and desfunktionalnom breeding hemorrhage : in / m to 10 mg / day for 6-8 Dnei.pri insufficient yellow body : 12.5 mg / d / m, in the two weeks after ovulation (if necessary, up to 11 weeks of pregnancy). Diagnosis of endogenous estrogen : in / m, 100 mg once. In the absence luteinova phases : inwards squeezed water, 200 to 300 mg a day, in two stages (morning and evening) for a period of 10 days (usually from the 17th to 26th day cycle). The substitution gormonoterapii in menopause for a reception estrogen : 2 caps. a day for about 10-12 Dnei.pri total lack of progesterone in women with inactive (non-existent) ovaries (egg donation) : intrawaginalno (in the b 1427d ackground estrogenna therapy) to 1 caps. a day for 13 and the 14th days of the cycle, followed by 1 caps. twice a day from the 15th to 25th day of the cycle, with the 26th day in the case of pregnancy increases the dose of 1 caps. a day each week to a maximum (6 capsules per day), divided into 3 admission; Course-to 60 Dnei.podderjanie luteinova phase at the time of the cycle of reproduction : 4-6 caps. a day from the date of injections horioniceski gonadotropina to 12 Weeks беременности.Поддерж��ние luteinova phase of a spontaneous or induzirovannom menstrual cycle as barrenness associated with the violation of the yellow body : 2-3 caps. a day from the 17th round of the day for 10 days; in the event of a delay menstruation and pregnancy diagnosis treatment to be продолжено.Профилакт��ка attacks and threatening attacks occurring against the backdrop of lack of progesterone : on 1-2 caps. twice a day every day until 12 weeks Beremennosti.gel : Local 1 applikatora dose (2.5 g gel) are on the surface of each breast twice a day, including in the days of their menstrual cycle.

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