Testosterone

Chemical name

(17бета)-17-Гидроксиандр ост-4-ен-3-он

Gross

C19-H28-O2

Characteristics

White or svetlo-kremovi crystalline powder odourless, virtually nerastvorim in water, soluble in dioxane and vegetable oils, rectificirovannom (1:5) and absolute (1:6) alcohol, chloroform (1:2), radio (1:100), poorly soluble in atiloleate.

Of drugs

The drugs-androgennoe, protivoopujolevoe, anabolicescoe. In kletkah-misheniah skin, prostate, seed and grain epididimusa restored to 5-alfa-reduktaza 5-альфа-дигидротестос��ерона. Last specifically interacts with the receptor zitoplazmaticescoy membrane on the surface of cells and enters the nucleus. In some tissues, including Hypothalamus becoming estradiol. Besides development of male sexual organs and secondary sexual characteristics, the growth of bone and muscle tissue; Nitrogen reduces fat and excretion of trace elements; Ingibiruet develop and release gipofizom LG and opened; Anabolizm increases and delays catabolised protein increases the exchange of nitrogen substances sufficient intake belkovom nutrition, stimulating products Erythropoietin and Eritropoaiz.posle intake of the biotransformiroetsa mainly in the liver and little androsterona active and inactive etioholanolona that excretiruyutza with urine in the form of glukuronidov and sulphate; about 6% rate of return faeces in an unmodified form; T_1/2 ranging from 10 to 100 minutes; 98% is associated with proteins (mostly globulinami connecting the estradiol). Bioavailability testosterone undekanoata dissolved in oleic acid is 45-48%. In doing so, he absorbed through the lymphatic system thin intestines, enters the breast lymphatic depressions, and then to the upper ultimate suicide, and the system bloodstream, bypassing the liver. More high bioavailability is vnesosudistami users (oil solutions testosterone esters) forms. Esters lipofilna vary speeds absorption, distribution and breeding : testosterone propionat has quickly in the first day, and izokapronat fenilpropionat-in the range of 2-14 days, the caprinovogo ester still 3-4 weeks. Both fast and slow esters in the same product made rapid and prolonged (more than four weeks) effect in the imposition of oil parenteral solutions, the use of implants and nakozhnykh plastyrnah of slow release.

Indications

Under androgenov men : delay puberty oligospermia, postcastrationny syndrome, nedorazvitie genitals, gipopituitrizm, infertility breach spermatogeneza, menopausal syndrome, impotence, Osteoporoz.u women : giperestrogenizm, mioma uterus, endometriosis, climax (in combination with estrogenami) syndrome fifth paragraph voltage, breast cancer, osteoporosis.

Contraindications

Hypersensitivity established or projected carcinoma of prostate and / or breast cancer, or principally nefrotical phase nephritis, gipercalziemia, oedema, the liver and kidneys, diabetes, prostate hypertrophy cancer with the symptoms of shock, and cardiac insufficiency koronarnaya, myocardial infarctions disease, atherosclerosis in older men, pregnancy, breast-feeding.

Side-Effects

Early puberty, anomalies and cancer prostate cancer, increased sexual initiation and increasing resort, the increase of the penis, priapizm, oligospermia, decline in the volume, the delay sodium and water, premature closure of growth zones bones; Headache, depression, anxiety, insomnia, parestesia, bleeding in the digestive tract, nausea, jaundice holetsatical, etc. androgenne effects (girsutizm, palliative, mask, etc.).

Patient interaction

Increases effect anti proximity (warfarin, nikumalon, fenilin) and gipoglikemicakih funds ingibiruet withdrawal of cyclosporine. Barbiturates and alcohol reduces the effect.

Precautions

When androgenzawisimah adverse events continue treatment until their disappearance and resuming lower doses.

Dosing and Administration

Inside (capsules, tablets); In / m, p / c (implants, oil solutions selected ethers, or their combinations). The mode is selected individually, depending on the disease, sex, age and dosage forms.

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