Directory → Antineoplastic funds → Antineoplastic hormonal and hormone antagonists → Zitazonium
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ZitazoniumSee also TamoxifenRoman nameZitazoniumPharmacokineticsIt absorbed and metabolised in the liver with the formation of several metabolites. C_max (after single dose) is achieved within 4-7 hours Stable level tamoksifena concentration in the serum are usually recorded after 3-4-nedelnogo reception. Place in two phases : the start-T_1/2 7-14 h, followed by the slow terminal T_1/2-7 days. Provided mainly in the form of kongugatov mainly spread, and a few displays with urine.IndicationsEstrogenozawisimy breast cancer among women (especially in menopause), and thoracic surgery for men; Cancer of the ovaries, endometrium, kidney, melanoma, sarcoma of soft tissues (subject to a tumour oestrogen receptors), prostate cancer and cancer resistance to other LANs.Pregnancy and lactationContraindicated in pregnancy. At the time of treatment should stop breastfeeding.ContraindicationsHypersensitivity expressed throm, pregnancy, breast-feeding.Patient interactionTogether with the appointment zitostatikami the risk тромбообразования.По��енцирует antikoagulyazionny effect of coumarin derivatives (eg racumin). Dioretiki tiazidovy number increased risk gipercalziemii. When coupled with a teghafoorom potentially a chronic hepatitis and cirrhosis (two reports), with other hormonal drugs (especially estrogensoderjasimi contraceptives), the mutual reduction actions.PrecautionsThe regular gynaecological check-ups. When crowianistah emissions or bleeding from the vagina, signs of atherosclerosis lower limbs (pain in the feet or swelling), cerebral pulmonary artery (adults) admission should be discontinued. At the beginning of treatment should be determined calcium concentration in the serum of patients with metastasis to the bone (when expressed violations You must suspend). Women leading sexually active because of possible moment at the time and in the two months after the end of treatment, use of mechanical or negormonalnah contraceptives.Dosing and AdministrationThe inside is not liquid, squeezed small amount of fluid intake set individually. The standard dose of 20 mg daily dose of 20-40 mg in 1 or 2 admission (morning and evening) daily (long-term).Storage conditionsList B. In the dark place at a temperature of 15-25 ° CThe registration014630/01-2002Shelf life4 |
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