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Regeneranta and reparanta
The groupNormal living organism with a continuous process of replacing moribund cells and tissues that came to be known as the physiological regeneration. Different tissues differ in ability to recover (regeneration), which is higher the more the role of physiological regeneration in the structure and functioning tissue. Cells blood, mucous membranes decreases, coating skin cancer, etc. quickly updated, and therefore fabric, they do form have high potential regeneration. Instead, the neuronal and muscle cell regeneration potential is minimal (close to zero). Under the influence of age-related diseases, toxic and environmental factors, radiation process physiological regeneration lock. The effect of some drugs, including immunosuppressants antineoplastic drugs, corticosteroids, some antibiotics and NPVS etc. Oppression of physiological regeneration accompanied by the development of human metabolism, leiko- emergence and trombozitopenia, anaemia, defeat mucous membranes, incl. Stomach, etc. Medicines can increase the speed and intensity of physiological regeneration has been called stimulants regeneration or regenerantov.
Restoration of tissues and organs, died as a result of trauma, injury or malnutrition (intoxication hypoxia, infection, etc.) is the process of Reparative regeneration. Accordingly, the drugs, as well as the ability to stimulate regeneration (reparativuyu regeneration) - reparantami. In the end, reparations are replacing pockets necrosis specific and / or connective (has the highest potential regeneration) cloth.
The regenerative mechanism of action involves increasing biosynthesis purinovykh and pirimidinovykh grounds RNA, functional and enzymatic cellular elements, including phospholipids membranes, as well as the stimulation reduplication of DNA and cell division. It should be noted that the process of biosynthesis in both physiological, and Reparative regeneration needs substratne Security (indispensable amino and fatty acids, trace elements, vitamins). In addition, the process of protein biosynthesis of phospholipids and is highly inefficient and requires stimulation of the energy (energy materials). These funds substratno and energy flow for the regeneration of aktovegin, solcoseril, etc. The effect of these drugs is often difficult otdifferencirovati of regenerirutego own.
In accordance with the marketplace (and the objectives of pharmacotherapy) stimulants regeneration and reparations conditionally divided into publecletocnae (universal) and tkanespecificskie. By publecletocnam amphetamine acting regenerirutuyu any tissue of 25.06.1997 (see Anaboliki), non-steroidal anaboliki-sodium desoksiribonukleat (derinat) metilurazil, inozin, etc. (see Anaboliki) and vitamins plastic exchange (see Vitamins and vitaminopodobne means).
Tkanespecificskie stimulants regeneration process are preparations with a different mechanism of action, in the combined group for the electoral act to either cloth or system. Funds restore education uniform of blood in the bone marrow are amphetamine blood (see gemopoaiza Stimulants).
Vitamin D (see Vitamins and vitaminopodobne vehicles) and preparations calcium, phosphorus and fluorine (see Macro and micro), hondroitin-sulfat (struktum) osteoguenon and others have the ability to enhance regenerative processes in the bone tissue (see Corrector metabolism of bone and cartilage tissue). Recovery processes in cartilage tissue promotes and provides vitamins C, E (see Vitamins and vitaminopodobne tools) hondroitin-fosfat (see Corrector metabolism of bone and cartilage tissue), and other means. One of the most representative group of drugs-stimulants regeneration and reparations mucous membrane syndrome. These funds help to accelerate the process of healing from erosivno-yazvennah mucous membrane syndrome. The repairing of the products of the group, in addition to stimulation of protein biosynthesis and cell division, includes braking franco-radikalnah reactions and liberation of lysosomal enzymes. An additional factor playing a significant role in generating the repairing effect is to strengthen local prostaglandines synthesis, to improve microcirculation disturbances in the stomach lining.
By means of promoting regeneration and repair mucous membrane removes the bismuth Tripotassium ditsitrat (de-nol) dalargin, sodium alginat, ventramin, polivinox, etc. �астроэнтерологическ��й Practice reparanta appointed after remission, and resistance to conventional methods, including in the case of long-term nerubtsuthan ulceration and patients are elderly.
The largest number of drugs among tkanespecificakih stimulants regeneration affects regeneration and repair skin. Testimony to the use of these funds are trudnozazivate wounds, trophic ulcers, burns, decubitus, etc. Most of this group, incl. containing active ingredients from plants, the ability to promote skin regeneration combined with other effects : противовоспалительны м (ointment Biovenol and calendula), antioxidant (revalid), the restoration of balance and coagulation systems protivosvertawatei blood improved local circulation and trophic skin (gepatrombin, ximedona tablets, etc.) and antibacterial (polivinox, gialuronat zinc fitostimulin etc.). The antibacterial action is the most significant, given the increased risk of HIV infection of the skin. The main purpose of the appointment of these drugs is to stimulate regeneration and dermal connective tissue in the area of destruction. However, it should be noted that the healing epitelizaciei skin possibly with surface processes (eroziah, ulcers, burns, etc.). Deeper skin lesions heal with the formation of соединительно-тканно��о scars.
Regenerative effect on neuronal have nootropa (see Nootropa (neirometabolicescie stimulants)), zerebrolizin (see Nootropa (neirometabolicescie stimulants)) vinpocetin (see Corrector cerebral circulation), etc. Retinalamin (40b set fractions of the retina cattle or pigs) has been tkanespecificescoe regenerative effect on the retina eye.