Akrydilol

Roman name

Acridilole

The composition and the form of

1 tablet contains carvedilola 12.5, or 25 mg; in a contour acheikova packing 10 pcs. , in a cardboard 3 bundle packaging.

Of drugs

Gipotenzivne. Beta Blocker and альфа_1-адренорецепто��ы. It has its own simpatomimeticescoy activity.

Pharmacokinetics

Quickly and almost completely absorbed from the digestive tract. Associated with the plasma protein to 98-99%. Bioavailability is about 30% (effect of a "through the liver). Food intake slows, but does not affect the bioavailability. The liver is the metabolites of adrenoblokirtee effect. Older patients S_max 50% lower than those of the young.

Farmakodinamika

Has expressed vazodilatirtee and antianginalnoe effect. Impact round, reduces strain on the heart. In patients with heart failure increases the fraction release left Jeludocka.actie is in 1-2 h after administration.

Indications

Arterial hypertension (monotherapy or in combination therapy), a stable stenocardia.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity Arterial gipotenzia expressed aetiology, symptoms of weakness sinusovogo unit Av-blokada II degree (with the exception of patients with rhythm driver) unstable asthma or heart failure, pulmonary hypertension, or cardiogenny shock, bronchial asthma, chronic obstructive lung diseases with bronhospasticski component expressed liver failure, Children and Youth age (up to 18 years).

Side-Effects

From the nervous system and sensory organs : headache, fatigue, drowsiness, insomnia, impaired vision, reduced secreta slezna fluid Emotional Labilnosti.so the circulatory system and blood (blood, gemostaz) : arterial gipotenzia (plus golovokrugeniem, especially when vstavanii), the rhythm of the heart, Violations of peripheral blood circulation, slow or neritmicny pulse (less than 55 u. / min), the pain in the chest, increased Krovotochivosti.so part of the intestine : nausea, vomiting, dry mouth, diarrhea, �норексия.Аллергическ ие reactions : skin, Sapi.prochie : mialgia, artralgia, dyspnoea, bronhospazm, fear, ankle swelling, jaundice, giperglikemia, increased cholesterol levels in the blood, raising transaminaz in the blood, reducing the potency, the rapid decrease in body weight, a violation of urination.

Patient interaction

Do effect gipoglikemicakih PP increases of digoxin in the blood. Antiarrhythmic drugs anaesthetic means other gipotenzivee LAN (including beta-adrenoblokatora of eye drops), MAO inhibitors, simpatolitiki (rezerpin) glycosides cordial added effect. Zimetidin increases concentration in the blood, rifampicin - lowers. Incompatible with the / in the introduction of calcium antagonists (perhaps expressed slowing heart rhythm and expressed demotion AD).

Overdosing

Symptoms : arterial gipotenzia, aetiology, bronhospazm, smoking, heart failure, cardiogenny shock, the sense of violation, up to the coma, Generalized convulsions, the conductivity and stopping Serdza.lechenie : cardiac LAN, monitoring the cardiovascular and respiratory systems, the functions of the kidneys.

Precautions

The monitor kidney function in patients with renal insufficiency, ischemic heart disease, diffuse disease peripheral pressure, heart failure. The caution should be applied to diabetes, the recent deterioration in the current heart failure. If the heart failure in the face of treatment is recommended to increase the dose dioretikov, and if progressirovanii kidney failure drug be Otmeniti.v period of treatment is not recommended to drink alcoholic beverages. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, after eating, a small amount of liquid. Dose pick индивидуально.Артери��льная Hypertension : recommended dose for the first 14 days of treatment, 12.5 mg morning after breakfast and divided by two reception followed by dose 25 mg / day one morning or divided into two reception. After 14 days of exposure may be again Uvelicena.stabilnaya Drinking : initial dose, 12.5 mg twice a day, in 7-14 days under the supervision of a doctor dose may be increased to 25 mg twice a day. After 1-4 days, with the lack of efficiency and good endurance dose can be Uveliciti.ublaya daily dose should not exceed 100 mg (50 mg twice a day); patients over 70 years of age-50 mg (25 mg twice a day). The leading drug dose should be taken as soon as possible, but if the approach is receiving the next dose, the only take it without doubling. Lifting products need to be phased in over 1-2 Ned.esli product is not taken more than two weeks, the treatment needs to be put back on starting with the lowest dose.

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