Alfuzosin

Chemical name

N-[3-[(4-Амино-6,7-диметокс и-2-хиназолинил)метила мино]пропил]тетрагидр о-2- furancarboksamid (and as hydrochloride)

Gross

C19-H27-N5-O4

Of drugs

The drugs-antidizuricescoe. Normalizes breached urinating, including hyperplasia in the prostate gland. Yes blocks postsinapticalkie альфа_1-адренорецепто��ы in the prostate, urethra and triangular bladder. Reduces pressure uretre and reduces resistance to current urine; makes urinating and eliminates Dizuriu.posle intake of doses of 5 mg C_mah achieved after 3 h was 10.3 ng / J Bioavailability - 45-53%. Linking blood plasma to 90%. T_1/2-8 pm Most of the destroyed in the liver. Write mainly jelchew and faeces in the form of active metabolites and urine unchanged to (11%). Older patients absorbed faster C_max and bioavailability increased, the volume of distribution lowered, T_1/2 remains unchanged. When kidney failure volume distribution and the overall increase Cl (decreasing the bonding with the plasma protein). Even in the case of severe renal insufficiency (creatinine Cl - 15-40 ml / min) was not koumouliruet the intensive biotransformation.

Indications

Functional Disorders in bed sound hyperplasia prostate gland.

Contraindications

Hypersensitivity, ortostatical gipotenzia (in history), admission etc. альфа-адреноблокатор��в.

Side-Effects

Headache, dizziness, noise in the ears, weakness, drowsiness, fatigue, ortostatical gipotenzia, tachycardia, exacerbation of the symptoms of stroke (in patients with ischemic heart disease), dry mouth, nausea, pain in epigastria, diarrhoea, swelling, redness of skin, skin rashes, itching of the skin.

Patient interaction

Incompatible with the others. альфа_1-адренолитикам��. Do effects antigipertenziveh funds, including Toronto, and general anesthetics (possible instability in the AD anaesthesia).

Overdosing

Symptoms : arterial Gipotenzia.lechenie : introduction sossoudossoujiwath of solutions of high explosives, adding BCC; Dialysis weak.

Precautions

A correction doses in the appointment of patients with ischemic heart disease, renal failure, arterial hypertension (in the background gipotenziveh funds).

Dosing and Administration

The inside is not liquid, 5 mg morning and evening (daily dose of 10 mg); Starting treatment with evening reception. Older and patients receiving antigipertenzivnuu therapy, 5 mg / day evening, if necessary increase the dose to 10 mg / day (maximum).

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