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Dalfaz retard

See also Alfuzosin

Roman name

Dalfaz retard

The composition and the form of

Male Film-coated-1 tabl.alfuzozin (as hydrochloride) - 2.5 megawatts blistere 15 pcs. ; in the paper cartons 2 Blister.tabletki Film-coated, retard-1 tabl.alfuzozin (as hydrochloride), 5 megawatts blistere 14 pcs. ; in a cardboard box 4 blisters.

Pharmacokinetics

Once inside doses 5 mg C_max achieved through 3h Linking blood plasma to 90%, T_1/2-8 pm Most of metabolized. Write mainly jelchew and faeces in the form of inactive metabolites. Older people have lost happening more quickly C_max bioavailability and-above, the lower T_1/2 remains unchanged. In patients with renal insufficiency volume distribution and the overall Cl increased as a result of a reduction in bonding with plasma proteins. Even with severe renal insufficiency (creatinine Cl - 15-40 ml / min) is not happening cumulation (high biotransformation). In chronic heart failure pharmacokinetic parameters are changed.

Farmakodinamika

Reduces pressure uretre and reduces resistance to current urine; Makes urinating and eliminates dizuriu. In therapeutic doses does not affect the альфа_1-адренорецепто��ы Vascular wall.

Indications

Functional Disorders in bed sound hyperplasia prostate gland.

Contraindications

Hypersensitivity, ortostatical gipotenzia in history, the lack of serious liver, simultaneous other альфа-адреноблокатор��в.

Side-Effects

Most, nausea, diarrhoea, gastralgia, headache, dizziness, weakness. Less often ortostatical gipotenzia, oedema, drowsiness, fatigue, tachycardia, dry mouth, reddening of skin, skin rashes, itching of the skin. Sometimes, worsening symptoms strokes (in patients with ischemic heart disease).

Patient interaction

Incompatible with the others. альфа_1-адреноблокато��ами. Do effects antigipertenziveh drugs and general anesthetics.

Precautions

Be wary appoint patients with ischemic heart disease, kidney disease, the sick arterial hypertension receiving gipotenzivee funds.

Storage conditions

List B. In dry place at a temperature below 25 ° C

Shelf life

3 years

The registration

013809/01

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