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DalfazSee also AlfuzosinRoman nameDalfazThe composition and the form ofMale Film-coated-1 tabl.alfuzozin (as hydrochloride) - 2.5 megawatts blistere 15 pcs. ; in the paper cartons 2 Blister.tabletki Film-coated, retard-1 tabl.alfuzozin (as hydrochloride), 5 megawatts blistere 14 pcs. ; in a cardboard box 4 blisters.CharacteristicsRound dvoyakovpuklae layer tablets (one white layer between two yellow), extended release of the substance. Alfuzosin is the active (to the inside) hinazolina derivative.PharmacokineticsOnce inside doses 5 mg C_max achieved through 3h Linking blood plasma to 90%, T_1/2-8 pm Most of metabolized. Write mainly jelchew and faeces in the form of inactive metabolites. Older people have lost happening more quickly C_max bioavailability and-above, the lower T_1/2 remains unchanged. In patients with renal insufficiency volume distribution and the overall Cl increased as a result of a reduction in bonding with plasma proteins. Even with severe renal insufficiency (creatinine Cl - 15-40 ml / min) is not happening cumulation (high biotransformation). In chronic heart failure pharmacokinetic parameters are changed.FarmakodinamikaReduces pressure uretre and reduces resistance to current urine; Makes urinating and eliminates dizuriu. In therapeutic doses does not affect the альфа_1-адренорецепто��ы Vascular wall.Clinical pharmacologyOlder people have absorbed faster C_max and bioavailability not increasing, the volume of the decreases. In renal failure (Cl creatinine 15-40 ml / min) was not koumouliruet the intensive biotransformation. In chronic heart failure farmakokinetika does not change.IndicationsFunctional Disorders in bed sound hyperplasia prostate gland.ContraindicationsHypersensitivity, ortostatical gipotenzia in history, the lack of serious liver, simultaneous other альфа-адреноблокатор��в.Side-EffectsMost, nausea, diarrhoea, gastralgia, headache, dizziness, weakness. Less often ortostatical gipotenzia, oedema, drowsiness, fatigue, tachycardia, dry mouth, reddening of skin, skin rashes, itching of the skin. Sometimes, worsening symptoms strokes (in patients with ischemic heart disease).Patient interactionIncompatible with the others. альфа_1-адреноблокато��ами. Do effects antigipertenziveh drugs and general anesthetics.OverdosingSymptoms : arterial Gipotenzia.lechenie : introduction sossoudossoujiwath of solutions of high explosives, adding BCC. Dialysis little (because of a high degree of binding to plasma proteins).PrecautionsBe wary appoint patients with ischemic heart disease, kidney disease, the sick arterial hypertension receiving gipotenzivee funds.Storage conditionsList B. In dry place at a temperature below 25 ° CShelf life3 yearsThe registration013809/02 |
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